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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rota, Cinzia Imberti, Barbara Pozzobon, Michela Piccoli, Martina De Coppi, Paolo Atala, Anthony Gagliardini, Elena Xinaris, Christodoulos Benedetti, Valentina Fabricio, Aline S. C. Squarcina, Elisa Abbate, Mauro Benigni, Ariela Remuzzi, Giuseppe Morigi, Marina |
| Description | Country affiliation: Italy Author Affiliation: Rota C ( Mario Negri Institute for Pharmacological Research, Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy.) |
| Abstract | Human amniotic fluid stem (hAFS) cells, a novel class of broadly multipotent stem cells that share characteristics of both embryonic and adult stem cells, have been regarded as promising candidate for cell therapy. Taking advantage by the well-established murine model of acute kidney injury (AKI), we studied the proregenerative effect of hAFS cells in immunodeficient mice injected with the nephrotoxic drug cisplatin. Infusion of hAFS cells in cisplatin mice improved renal function and limited tubular damage, although not to control level, and prolonged animal survival. Human AFS cells engrafted injured kidney predominantly in peritubular region without acquiring tubular epithelial markers. Human AFS cells exerted antiapoptotic effect, activated Akt, and stimulated proliferation of tubular cells possibly via local release of factors, including interleukin-6, vascular endothelial growth factor, and stromal cell-derived factor-1, which we documented in vitro to be produced by hAFS cells. The therapeutic potential of hAFS cells was enhanced by cell pretreatment with glial cell line-derived neurotrophic factor (GDNF), which markedly ameliorated renal function and tubular injury by increasing stem cell homing to the tubulointerstitial compartment. By in vitro studies, GDNF increased hAFS cell production of growth factors, motility, and expression of receptors involved in cell homing and survival. These findings indicate that hAFS cells can promote functional recovery and contribute to renal regeneration in AKI mice via local production of mitogenic and prosurvival factors. The effects of hAFS cells can be remarkably enhanced by GDNF preconditioning. |
| File Format | HTM / HTML |
| ISSN | 15473287 |
| e-ISSN | 15578534 |
| DOI | 10.1089/scd.2011.0333 |
| Journal | Stem Cells and Development |
| Issue Number | 11 |
| Volume Number | 21 |
| Language | English |
| Publisher | Mary Ann Liebert, Inc. |
| Publisher Date | 2012-07-20 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Cell Biology Discipline Hematology Amniotic Fluid Cytology Cisplatin Adverse Effects Regeneration Stem Cells Acute Kidney Injury Chemically Induced Pathology Therapy Amniocentesis Animals Apoptosis Blood Urea Nitrogen Cell Differentiation Cell Movement Cell Survival Culture Media, Conditioned Metabolism Pharmacology Glial Cell Line-derived Neurotrophic Factor Immunohistochemistry Kidney Drug Effects Mice Mice, Inbred Nod Mice, Scid Stem Cell Transplantation Survival Analysis Transplantation, Homologous Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Developmental Biology Hematology |
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