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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Babiarz, Joshua E. Ravon, Morgane Sridhar, Sriram Ravindran, Palanikumar Swanson, Brad Bitter, Hans Weiser, Thomas Chiao, Eric Certa, Ulrich Kolaja, Kyle L. |
| Description | Country affiliation: United States Author Affiliation: Babiarz JE ( Nonclinical Safety, Hoffmann-La Roche, Nutley, New Jersey 07110, USA.) |
| Abstract | To gain insight into the molecular regulation of human heart development, a detailed comparison of the mRNA and miRNA transcriptomes across differentiating human-induced pluripotent stem cell (hiPSC)-derived cardiomyocytes and biopsies from fetal, adult, and hypertensive human hearts was performed. Gene ontology analysis of the mRNA expression levels of the hiPSCs differentiating into cardiomyocytes revealed 3 distinct groups of genes: pluripotent specific, transitional cardiac specification, and mature cardiomyocyte specific. Hierarchical clustering of the mRNA data revealed that the transcriptome of hiPSC cardiomyocytes largely stabilizes 20 days after initiation of differentiation. Nevertheless, analysis of cells continuously cultured for 120 days indicated that the cardiomyocytes continued to mature toward a more adult-like gene expression pattern. Analysis of cardiomyocyte-specific miRNAs (miR-1, miR-133a/b, and miR-208a/b) revealed an miRNA pattern indicative of stem cell to cardiomyocyte specification. A biostatistitical approach integrated the miRNA and mRNA expression profiles revealing a cardiomyocyte differentiation miRNA network and identified putative mRNAs targeted by multiple miRNAs. Together, these data reveal the miRNA network in human heart development and support the notion that overlapping miRNA networks re-enforce transcriptional control during developmental specification. |
| File Format | HTM / HTML |
| ISSN | 15473287 |
| e-ISSN | 15578534 |
| DOI | 10.1089/scd.2011.0357 |
| Journal | Stem Cells and Development |
| Issue Number | 11 |
| Volume Number | 21 |
| Language | English |
| Publisher | Mary Ann Liebert, Inc. |
| Publisher Date | 2012-07-20 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Cell Biology Discipline Hematology Cell Differentiation Micrornas Metabolism Myocytes, Cardiac Cytology Rna, Messenger Biological Markers Cells, Cultured Cluster Analysis Computational Biology Fetus Gene Expression Profiling Gene Expression Regulation Heart Growth & Development Genetics Oligonucleotide Array Sequence Analysis Phenotype Pluripotent Stem Cells Time Factors Transcription, Genetic Transcriptome |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Developmental Biology Hematology |
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