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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Messina, Andrea Puccinelli, Emanuela Gervasi, Pier Giovanni Longo, Vincenzo |
| Description | Country affiliation: Italy Author Affiliation: Messina A ( Istituto di Fisiologia Clinica CNR, Area della Ricerca CNR, via Moruzzi, 1, 56100 Pisa, Italy.) |
| Abstract | In this study, the constitutive and inducible expression of the CYP genes (1A1, 1A2, 1B1, 2B22, 3A22, 3A29 and 3A46), related transcriptional factors (AhR, CAR, PXR, and Nrf2) and the antioxidant enzymes SOD, catalase, GSSH-reductase and GSH-peroxidase were investigated in the liver, heart regions and coronary arteries of control pigs and pigs treated with ß-naphthoflavone (ßNF) or with rifampicin (RIF). Real-time PCR experiments and enzymatic or immunoblot assays showed that CYP1A1 was predominantly enhanced by ßNF in a similar manner in all the heart regions, whereas antioxidant enzyme activity was not affected. The rifampicin treatment resulted in an induction of CYP2B22 and CYP3As, at the transcriptional, activity and protein level in liver but not in heart nor in the coronary arteries, despite the expression of CAR and PXR in the cardiac tissues. These results obtained in vivo suggest that pig cardiac tissues may represent a useful model for humans. |
| File Format | HTM / HTML |
| ISSN | 00345288 |
| Issue Number | 1 |
| Volume Number | 94 |
| e-ISSN | 15322661 |
| Journal | Research in Veterinary Science |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-02-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Veterinary Medicine Aryl Hydrocarbon Hydroxylases Biosynthesis Coronary Vessels Drug Effects Cytochrome P-450 Cyp1a1 Cytochrome P-450 Cyp1a2 Cytochrome P-450 Cyp3a Cytochrome P-450 Enzyme System Heart Myocardium Metabolism Rifampin Pharmacology Beta-naphthoflavone Animals Catalase Cytochrome P-450 Cyp1b1 Enzyme Induction Real-time Polymerase Chain Reaction Veterinary Superoxide Dismutase Swine Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Veterinary |
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