NDLI: A proposed role for VEGF isoforms in sex-specific vasculature development in the gonad.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bott, R. C. Clopton, D. T. Cupp, A. S.
Description	Country affiliation: United States Author Affiliation: Bott RC ( Animal Science Department, University of Nebraska-Lincoln, Lincoln, NE 68583-0908, USA.)
Abstract	Many scientists have expended efforts to determine what regulates development of an indifferent gonad into either a testis or ovary. Expression of Sry and upregulation of Sox9 are factors that initiate formation of the testis-specific pathway to allow for both sex-specific vasculature and seminiferous cord formation. Migration of mesonephric precursors of peritubular myoid cells and endothelial cells into the differentiating testis is a critical step in formation of both of these structures. Furthermore, these events appear to be initiated downstream from Sry expression. Sertoli cell secretion of growth factors acts to attract these mesonephric cells. One hypothesis is that a growth factor specific for these cell linages act in concert to coordinate migration of both peritubular and endothelial cells. A second hypothesis is that several growth factors stimulate migration and differentiation of mesonephric 'stem-like' cells to result in migration and differentiation into several different cell lineages. While the specific mechanism is unclear, several growth factors have been implicated in the initiation of mesonephric cell migration. This review will focus on the proposed mechanisms of a growth factor, Vascular Endothelial Growth Factor, and how different angiogenic and inhibitory isoforms from this single gene may aid in development of testis-specific vascular development.
File Format	HTM / HTML
ISSN	09366768
e-ISSN	14390531
DOI	10.1111/j.1439-0531.2008.01179.x
Journal	Reproduction in Domestic Animals
Issue Number	Suppl 2
Volume Number	43
Language	English
Publisher	Wiley
Publisher Date	2008-07-01
Publisher Place	Germany
Access Restriction	Open
Subject Keyword	Discipline Reproductive Medicine Discipline Veterinary Medicine Discipline Zoology Gene Expression Regulation, Developmental Physiology Gonads Embryology Sox9 Transcription Factor Metabolism Signal Transduction Vascular Endothelial Growth Factors Animals Cytology Mice Models, Animal Sex Differentiation Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Animal Science and Zoology Endocrinology Biotechnology

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A Proposed Role for VEGF Isoforms in Sex-Specific Vasculature Development in the Gonad

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A Proposed Role for VEGF Isoforms in Sex-Specific Vasculature Development in the Gonad

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