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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ogino, Shin Miyamoto, Seiya Tenjin, Tomomi Kitajima, Rei Ojima, Kazuaki Miyake, Nobumi Funamoto, Yasuyuki Arai, Jun Tsukahara, Sachiko Ito, Yukie Tadokoro, Masanori Anai, Kiriko Tatsunami, Shinobu Kubota, Hiroshi Kaneda, Yasuhiro Yamaguchi, Noboru |
| Description | Country affiliation: Japan Author Affiliation: Ogino S ( Department of Neuropsychiatry, St Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa 216-8511, Japan. OginoshinNo.1@marianna-u.ac.jp) |
| Abstract | BACKGROUND: The high use of long-term antiparkinsonian anticholinergic drugs with antipsychotics has been identified as an important issue in the treatment of schizophrenia in Japan. The aim of this study was to evaluate the effects of gradual discontinuation of biperiden, an anticholinergic drug, on cognitive function and quality of life (QOL) in schizophrenia. METHODS: Thirty-four schizophrenic patients who had received a second-generation antipsychotic (SGA) with concomitant biperiden for at least 3 months were enrolled. Before and 4 weeks after discontinuation of biperiden, the Japanese version of the Brief Assessment of Cognition in Schizophrenia (BACS-J) and the Schizophrenia Quality of Life Scale (SQLS-J) were administered. Clinical evaluation also included the Positive and Negative Syndrome Scale (PANSS). To compare the practice effect on BACS-J, 10 chronic patients with schizophrenia were assessed without tapering biperiden. RESULTS: Biperiden was discontinued safely in most patients, and no emergent extrapyramidal symptoms were observed. Significant improvements were shown in attention, processing speed, and composite score, as measured by the BACS-J without practice effect. In addition, the psychosocial condition score on the SQLS-J and the general psychopathology score on the PANSS significantly improved after biperiden discontinuation. CONCLUSION: Discontinuation of long-term biperiden use may be warranted in patients with schizophrenia treated with SGAs, as it may improve cognitive function, subjective QOL, and psychiatric symptoms with no significant adverse effects. |
| File Format | HTM / HTML |
| ISSN | 02785846 |
| Issue Number | 1 |
| Volume Number | 35 |
| e-ISSN | 18784216 |
| Journal | Progress in Neuro-Psychopharmacology and Biological Psychiatry |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-01-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Psychiatry Biperiden Therapeutic Use Cognition Disorders Drug Therapy Muscarinic Antagonists Schizophrenia Adolescent Adult Analysis Of Variance Etiology Drug Administration Schedule Female Humans Longitudinal Studies Male Middle Aged Neuropsychological Tests Psychiatric Status Rating Scales Retrospective Studies Complications Young Adult Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biological Psychiatry Pharmacology |
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