| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Yang, Mei Mamy, Jules Wang, Qiang Liao, Yan-Hui Seewoobudul, Vasish Xiao, Shui-Yuan Hao, Wei |
| Description |
Country affiliation: China Author Affiliation: Yang M ( Department of Social Medicine, School of Public Health, Central South University, Changsha, China); Mamy J ( Department of Social Medicine, School of Public Health, Central South University, Changsha, China.); Wang Q ( Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, China.); Liao YH ( Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, China.); Seewoobudul V ( Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, China.); Xiao SY ( Department of Social Medicine, School of Public Health, Central South University, Changsha, China.); Hao W ( Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, China. Electronic address: weihao57@gmail.com.) |
| Abstract |
OBJECTIVE: To explore the association between the 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR polymorphisms with co-morbid borderline personality disorder (BPD) in female heroin-dependent patients. SUBJECTS AND METHODS: In a case control study, we compared the polymorphic distributions of 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR in 296 female heroin-dependent patients (including 61 patients with BPD and 235 without BPD) and 101 normal females by genotypes, alleles, and interaction between genes. RESULTS: Female heroin-dependent subjects with BPD have lower frequency of the high activity allele (L: 4 repeats (4R)) of MAOA-LPR than those female heroin-dependent subjects without BPD, and have higher 5-HTTVNTR 10R/10R genotype frequency than normal female controls, with adjusted P-value<0.05 (after adjusted for multiple testing by 1000-fold permutation tests) respectively. By MDR (Multifactor Dimensionality Reduction) analyses, the interactive effects between MAOA-LPR and 5-HTTVNTR, and among MAOA-LPR, 5-HTTVNTR and rs6311 were close to the significance level (P=0.05) in predicting the risk of co-morbidity of BPD and heroin dependence relative to normal female controls, with 1000-fold permutation testing P-value<0.06 however >0.05 respectively. CONCLUSION: 5-HTTVNTR and MAOA-LPR may have independent predictive effects on co-morbid BPD in female heroin-dependent patients; the gene-gene interactions between MAOA-LPR and 5-HTTVNTR, and among MAOA-LPR, 5-HTTVNTR and rs6311 might also be involved in the etiology of this co-morbidity. |
| File Format |
HTM / HTML |
| ISSN |
02785846 |
| Volume Number |
50 |
| e-ISSN |
18784216 |
| Journal |
Progress in Neuro-Psychopharmacology and Biological Psychiatry |
| Language |
English |
| Publisher |
Elsevier |
| Publisher Date |
2014-04-03 |
| Publisher Place |
Great Britain (UK) |
| Access Restriction |
One Nation One Subscription (ONOS) |
| Subject Keyword |
Discipline Psychiatry Asian Continental Ancestry Group Genetics Borderline Personality Disorder Catechol O-methyltransferase Dopamine Plasma Membrane Transport Proteins Heroin Dependence Monoamine Oxidase Receptor, Serotonin, 5-ht2a Serotonin Plasma Membrane Transport Proteins Adult Alleles Psychology Complications Case-control Studies Diagnosis, Dual (psychiatry) Epistasis, Genetic Female Genetic Association Studies Genetic Predisposition To Disease Genotype Humans Polymorphism, Genetic Journal Article Research Support, Non-u.s. Gov't |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Biological Psychiatry Pharmacology |
