NDLI: Source-based morphometry of gray matter volume in patients with schizophrenia who have persistent auditory verbal hallucinations.

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Source-based morphometry of gray matter volume in patients with schizophrenia who have persistent auditory verbal hallucinations.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kubera, Katharina M. Sambataro, Fabio Vasic, Nenad Wolf, Nadine D. Frasch, Karel Hirjak, Dusan Thomann, Philipp A. Wolf, R. Christian
Description	Country affiliation: Germany Author Affiliation: Kubera KM ( Center for Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Germany.); Sambataro F ( Brain Center for Motor and Social Cognition, Italian Institute of Technology, Parma, Italy.); Vasic N ( Department of Psychiatry and Psychotherapy III, Ulm University, Germany.); Wolf ND ( Central Institute of Mental Health, Department of Addictive Behavior and Addiction Medicine, Mannheim, Germany.); Frasch K ( Department of Psychiatry and Psychotherapy II,Ulm University, Germany.); Hirjak D ( Center for Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Germany.); Thomann PA ( Center for Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Germany.); Wolf RC ( Center for Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Germany. Electronic address: christian.wolf@med.uni-heidelberg.de.)
Abstract	Abnormal structure of frontal and temporal brain regions has been suggested to occur in patients with schizophrenia who have frequent auditory verbal hallucinations (AVH). However, it is unknown whether this is specific to this patient subgroup. This study tested the hypothesis that frontotemporal gray matter volume changes would characterize patients with persistent AVH (pAVH) in contrast to healthy controls and patients without AVH. Using structural magnetic resonance imaging at 3T, we studied 20 patients with schizophrenia and 14 matched healthy controls. Ten patients were classified as having chronic and treatment resistant AVH, whereas the remaining 10 patients either never had AVH in the past or were in full remission with regard to AVH (nAVH). Using a multivariate statistical technique for structural data, i.e. 'source-based morphometry' (SBM), we investigated naturally grouping patterns of gray matter volume variation among individuals, the magnitude of their expression between-groups and the relationship between gray matter volume and AVH-specific measures. SBM identified a reduction of medial and inferior frontal, insular and bilateral temporal gray matter volume between pAVH and nAVH. This pattern did not differ between nAVH patients and controls and was associated with 'physical' AVH characteristics (such as symptom duration, location, frequency and intensity) in the pAVH patient group. These results suggest that a pattern of lower gray matter volume in medial frontal, insular and bilateral temporal cortical regions differentiates between patients with persistent AVH and non-hallucinating patients. Moreover, the data support a specific role of this neural pattern in AVH symptom expression.
File Format	HTM / HTML
ISSN	02785846
Volume Number	50
e-ISSN	18784216
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Language	English
Publisher	Elsevier
Publisher Date	2014-04-03
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Psychiatry Hallucinations Pathology Nerve Fibers, Unmyelinated Schizophrenia Adult Atrophy Case-control Studies Female Frontal Lobe Complications Humans Magnetic Resonance Imaging Male Neuroimaging Temporal Lobe Young Adult Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Biological Psychiatry Pharmacology

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Source-based morphometry of gray matter volume in patients with schizophrenia who have persistent auditory verbal hallucinations.

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Source-based morphometry of gray matter volume in patients with schizophrenia who have persistent auditory verbal hallucinations.