NDLI: Mitochondrial DNA copy number is reduced in male combat veterans with PTSD.

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Mitochondrial DNA copy number is reduced in male combat veterans with PTSD.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bersani, Francesco Saverio Morley, Claire Lindqvist, Daniel Epel, Elissa S. Picard, Martin Yehuda, Rachel Flory, Janine Bierer, Linda M. Makotkine, Iouri Abu-Amara, Duna Coy, Michelle Reus, Victor I. Lin, Jue Blackburn, Elizabeth H. Marmar, Charles Wolkowitz, Owen M. Mellon, Synthia H.
Description	Country affiliation: Italy Author Affiliation: Bersani FS ( Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA); Morley C ( Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA.); Lindqvist D ( Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA); Epel ES ( Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA); Picard M ( Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, USA.); Yehuda R ( Department of Psychiatry, MSSM/James J. Peters Veterans Administration Medical Center, New York, NY, USA.); Flory J ( Department of Psychiatry, MSSM/James J. Peters Veterans Administration Medical Center, New York, NY, USA.); Bierer LM ( Department of Psychiatry, MSSM/James J. Peters Veterans Administration Medical Center, New York, NY, USA.); Makotkine I ( Department of Psychiatry, MSSM/James J. Peters Veterans Administration Medical Center, New York, NY, USA.); Abu-Amara D ( Department of Psychiatry, Steven and Alexandra Cohen Veterans Center for Posttraumatic Stress and Traumatic Brain Injury, New York, NY, USA.); Coy M ( Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA.); Reus VI ( Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA.); Lin J ( Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.); Blackburn EH ( Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.); Marmar C ( Department of Psychiatry, Steven and Alexandra Cohen Veterans Center for Posttraumatic Stress and Traumatic Brain Injury, New York, NY, USA.); Wolkowitz OM ( Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA. Electronic address: Owen.Wolkowitz@ucsf.edu.); Mellon SH ( Department of OB/GYN and Reproductive Science, University of California San Francisco, San Francisco, CA, USA.)
Abstract	INTRODUCTION: Mitochondrial abnormalities may be involved in PTSD, although few studies have examined this. Mitochondrial DNA copy number (mtDNAcn) in blood cells is an emerging systemic index of mitochondrial biogenesis and function. The present study assessed mtDNAcn in male combat-exposed veterans with PTSD compared to those without PTSD as well as its correlation with clinical scales. METHODS: mtDNAcn was assessed with a TaqMan multiplex assay in granulocytes of 43 male combat veterans with (n=43) or without (n=44) PTSD. Twenty of the PTSD subjects had co-morbid major depressive disorder (MDD). The Clinician Administered PTSD Scale (CAPS), the Positive and Negative Affect Schedule (PANAS), the Early Trauma Inventory (ETI) and the Beck Depression Inventory II (BDI-II) were used for the clinical assessments. All analyses were corrected for age and BMI. RESULTS: mtDNAcn was significantly lower in subjects with PTSD (p<0.05). Within the PTSD group, those with moderate PTSD symptom severity had relatively higher mtDNAcn than those with mild or severe symptoms (p<0.01). Within the PTSD group, mtDNAcn was positively correlated with PANAS positive subscale ratings (p<0.01) but was not significantly correlated with PANAS negative subscale, ETI or BDI-II ratings. DISCUSSION: This study provides the first evidence of: (i) a significant decrease of mtDNAcn in combat PTSD, (ii) a possible 'inverted-U' shaped relationship between PTSD symptom severity and mtDNAcn within PTSD subjects, and (iii) a direct correlation of mtDNAcn with positive affectivity within PTSD subjects. Altered mtDNAcn in PTSD may reflect impaired energy metabolism, which might represent a novel aspect of its pathophysiology.
File Format	HTM / HTML
ISSN	02785846
Volume Number	64
e-ISSN	18784216
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Language	English
Publisher	Elsevier
Publisher Date	2016-01-04
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Psychiatry Dna Copy Number Variations Dna, Mitochondrial Blood Stress Disorders, Post-traumatic Genetics Veterans Adult Age Factors Body Mass Index Comorbidity Depressive Disorder, Major Complications Epidemiology Humans Male Psychiatric Status Rating Scales Severity Of Illness Index War Journal Article Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Biological Psychiatry Pharmacology

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