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For whom the endocannabinoid tolls: Modulation of innate immune function and implications for psychiatric disorders.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Henry, Rebecca J. Kerr, Daniel M. Finn, David P. Roche, Michelle
Description	Country affiliation: Ireland Author Affiliation: Henry RJ ( Physiology, School of Medicine, National University of Ireland, Galway, Ireland); Kerr DM ( Physiology, School of Medicine, National University of Ireland, Galway, Ireland); Finn DP ( Pharmacology and Therapeutics, School of Medicine, National University of Ireland, Galway, Ireland); Roche M ( Physiology, School of Medicine, National University of Ireland, Galway, Ireland)
Abstract	Toll-like receptors (TLRs) mediate the innate immune response to pathogens and are critical in the host defence, homeostasis and response to injury. However, uncontrolled and aberrant TLR activation can elicit potent effects on neurotransmission and neurodegenerative cascades and has been proposed to trigger the onset of certain neurodegenerative disorders and elicit detrimental effects on the progression and outcome of established disease. Over the past decade, there has been increasing evidence demonstrating that the endocannabinoid system can elicit potent modulatory effects on inflammatory processes, with clinical and preclinical evidence demonstrating beneficial effects on disease severity and symptoms in several inflammatory conditions. This review examines the evidence supporting a modulatory effect of endocannabinoids on TLR-mediated immune responses both peripherally and centrally, and the implications for psychiatric disorders such as depression and schizophrenia.
File Format	HTM / HTML
ISSN	02785846
Volume Number	64
e-ISSN	18784216
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Language	English
Publisher	Elsevier
Publisher Date	2016-01-04
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Psychiatry Endocannabinoids Metabolism Immunity, Innate Physiology Mental Disorders Immunology Animals Humans Drug Therapy Neuroimmunomodulation Toll-like Receptors Journal Article Research Support, Non-u.s. Gov't Review
Content Type	Text
Resource Type	Article
Subject	Biological Psychiatry Pharmacology

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