NDLI: Isolation and cytotoxic activity of selaginellin derivatives and biflavonoids from Selaginella tamariscina.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, Guo-gang Jing, Ying Zhang, Hong-mei Ma, En-long Guan, Jin Xue, Feng-ning Liu, Hong-xia Sun, Xiao-ya
Description	Author Affiliation: Zhang GG ( College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, P. R. China. Zhangguogang821@hotmail.com)
Abstract	Five selaginellin derivatives, including two new selaginellins termed selaginellins M (1) and N (2), and three previously identified compounds, selaginellin (3), selaginellin A (4), and selaginellin C (5), were isolated from the Selaginella tamariscina (Beauv.) Spring plant. In addition, four known biflavonoids, namely neocryptomerin ( 6), hinokiflavone (7), pulvinatabiflavone (8), and 7''- O-methylamentoflavone (9), were also isolated. The structures of new compounds 1 and 2 were elucidated by spectroscopic analysis. The cytotoxic activity of compounds 1- 9 was evaluated against a small panel of human cancer cell lines, including U251 (human glioma cells), HeLa (human cervical carcinoma cells), and MCF-7 (human breast cancer cells). The two new selaginellins, selaginellins M (1) and N (2), showed medium activity against the human cancer cell lines.
File Format	HTM / HTML
ISSN	00320943
Issue Number	4
Volume Number	78
e-ISSN	14390221
Journal	Planta Medica
Language	English
Publisher	George Thieme
Publisher Date	2012-03-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Botany Antineoplastic Agents, Phytogenic Pharmacology Biflavonoids Selaginellaceae Chemistry Biphenyl Compounds Breast Neoplasms Drug Therapy Cell Line, Tumor Cyclohexanones Cytotoxins Glioma Hela Cells Drug Effects Humans Molecular Structure Phytotherapy Plant Extracts Letter
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Drug Discovery Analytical Chemistry Molecular Medicine Pharmacology Complementary and Alternative Medicine Pharmaceutical Science

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