NDLI: Anti-hyperglycemic and anti-hypercholesterolemic effects of Aloe vera leaf gel in hyperlipidemic type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Huseini, Hasan Fallah Kianbakht, Saeed Hajiaghaee, Reza Dabaghian, Fataneh Hashem
Description	Country affiliation: Iran Author Affiliation: Huseini HF ( Department of Pharmacology and Applied Medicine, Research Institute of Medicinal Plants, ACECR, Karaj, Iran. skianbakht@yahoo.com)
Abstract	Diabetes mellitus type 2 with dyslipidemia is a common disease. Previous studies suggest that aloe (Aloe vera L.) leaf gel may positively affect the blood glucose and lipid levels in dyslipidemic type 2 diabetic patients. Thus, in this randomized double-blind placebo-controlled clinical trial with hyperlipidemic (hypercholesterolemic and/or hypertriglyceridemic) type 2 diabetic patients aged 40 to 60 years not using other anti-hyperlipidemic agents and resistant to daily intake of two 5 mg glyburide tablets and two 500 mg metformin tablets, the efficacy and safety of taking aloe gel (one 300 mg capsule every 12 hours for 2 months) combined with the aforementioned drugs in treatment of 30 patients were evaluated and compared with the placebo group (n = 30). The aloe gel lowered the fasting blood glucose, HbA1c, total cholesterol, and LDL levels significantly (p = 0.036, p = 0.036, p = 0.006, and p = 0.004, respectively) without any significant effects on the other blood lipid levels and liver/kidney function tests (p > 0.05) compared with the placebo at the endpoint. No adverse effects were reported. The results suggest that aloe gel may be a safe anti-hyperglycemic and anti-hypercholesterolemic agent for hyperlipidemic type 2 diabetic patients.
File Format	HTM / HTML
ISSN	00320943
Issue Number	4
Volume Number	78
e-ISSN	14390221
Journal	Planta Medica
Language	English
Publisher	George Thieme
Publisher Date	2012-03-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Botany Aloe Chemistry Diabetes Mellitus, Type 2 Drug Therapy Hypercholesterolemia Hypoglycemic Agents Administration & Dosage Phytotherapy Methods Plant Extracts Adult Blood Double-blind Method Female Gels Glyburide Therapeutic Use Humans Hyperglycemia Hyperlipidemias Male Metformin Middle Aged Placebos Plant Leaves Clinical Trial Comparative Study Journal Article Randomized Controlled Trial Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Drug Discovery Analytical Chemistry Molecular Medicine Pharmacology Complementary and Alternative Medicine Pharmaceutical Science

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