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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gökirmak, Tufan Denison, Fiona C. Laughner, Beth J. Paul, Anna-Lisa Ferl, Robert J. |
| Description | Country affiliation: United States Author Affiliation: Gökirmak T ( Program in Plant Molecular and Cellular Biology, University of Florida, Gainesville, FL 32611, USA.); Denison FC ( Department of Horticultural Sciences, University of Florida, Gainesville, FL 32611, USA.); Laughner BJ ( Department of Horticultural Sciences, University of Florida, Gainesville, FL 32611, USA.); Paul AL ( Department of Horticultural Sciences, University of Florida, Gainesville, FL 32611, USA); Ferl RJ ( Program in Plant Molecular and Cellular Biology, University of Florida, Gainesville, FL 32611, USA) |
| Abstract | 14-3-3s are evolutionarily conserved eukaryotic regulatory proteins that are involved in diverse biological processes. The common mode of action for the 14-3-3 proteins is through the binding of phosphorylated target proteins. In many species, multiple 14-3-3 isoforms exist and these different isoforms can exhibit distinct ranges of target interactions. The dimerization of 14-3-3s is central to their function. 14-3-3 isoforms can form different combinations of homo- and heterodimers, which contribute to the broad functional diversity of the family. In this study, we showed that phosphomimetic mutation of a conserved serine residue in the dimerization interface of 14-3-3 isoforms, Ser-62, not only affects the ability of Arabidopsis 14-3-3ω to form homodimers, but alters the range of 14-3-3 family members with which it can form heterodimers. Furthermore, we demonstrated that the phosphorylation status of Ser-62 can regulate the binding of 14-3-3ω to target proteins, suggesting that Ser-62 might be a conserved key element to modulate target binding in both plants and animals. |
| File Format | HTM / HTML |
| ISSN | 09819428 |
| Journal | Plant Physiology and Biochemistry |
| Volume Number | 97 |
| e-ISSN | 18732690 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-12-01 |
| Publisher Place | France |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Botany Discipline Biochemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Physiology Plant Science |
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