NDLI: The novel anti-hyperglycemic effect of Paeoniae radix via the transcriptional suppression of phosphoenopyruvate carboxykinase (PEPCK).

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The novel anti-hyperglycemic effect of Paeoniae radix via the transcriptional suppression of phosphoenopyruvate carboxykinase (PEPCK).

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Juan, Y-C Tsai, W-J Lin, Y-L Wang, G-J Cheng, J-J Yang, H-Y Hsu, C-Y Liu, H-K
Description	Author Affiliation: Juan YC ( Institute of Pharmacology, University of Yang Ming, Taipei, Taiwan, ROC.)
Abstract	The antidiabetic actions of Paeoniae Radix involve stimulating glucose uptake and reducing glucose absorption. However, the importance of this herb in the transcriptional regulation of hepatic gluconeogenesis has not previously been investigated, although hepatic gluconeogenesis contributes the most to fasting hyperglycemia. Using rats with streptozotocin-induced diabetes and db/db mice, the dose- and time-dependent suppressive effects of the ethanol extract of Paeoniae Radix (PR-Et) on diabetic hyperglycemia and phosphoenopyruvate carboxykinase (PEPCK) transcription are first demonstrated. Second, by employing H4IIE cells, the inhibitory action of PR-Et on both dexamethasone- and 8-bromo-cAMP-induced-PEPCK expression was also confirmed without causing any cytotoxicity. In addition, this inhibitory effect could be sustained for over 24 h with repeated treatment. Most importantly, PR-Et's action was unaffected by either insulin desensitization or palmitate stimulation. Finally, paeonol and paeoniflorin, two well-known constituents in Paeoniae Radix, did not suppress PEPCK expression at testing concentration. In conclusion, it was clearly demonstrated that transcriptional inhibition of gluconeogenesis is one of the important antidiabetic actions of Paeoniae Radix. Future development of this herb as a dietary supplement or drug should bring substantial benefits for the diabetic population.
File Format	HTM / HTML
ISSN	09447113
Issue Number	8-9
Volume Number	17
Journal	Phytomedicine
e-ISSN	1618095X
Language	English
Publisher	Elsevier
Publisher Date	2010-07-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Complementary Therapies Diabetes Mellitus, Experimental Drug Therapy Drugs, Chinese Herbal Therapeutic Use Gluconeogenesis Drug Effects Hypoglycemic Agents Liver Paeonia Chemistry Phosphoenolpyruvate Carboxykinase (gtp) Metabolism 8-bromo Cyclic Adenosine Monophosphate Acetophenones Isolation & Purification Pharmacology Animals Benzoates Bridged Compounds Cell Line Dexamethasone Genetics Dose-response Relationship, Drug Gene Expression Glucosides Humans Insulin Male Mice Mice, Inbred C57bl Mice, Knockout Monoterpenes Palmitic Acid Phytotherapy Plant Roots Rats Rats, Sprague-dawley Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Molecular Medicine Pharmacology Complementary and Alternative Medicine Pharmaceutical Science

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Comparative pharmacokinetic study of paeoniflorin after oral administration of decoction of Radix Paeoniae Rubra and Radix Paeoniae Alba in rats.

Application of quantitative 1H-NMR method to determination of paeoniflorin in Paeoniae radix.

Pharmacokinetic properties of paeoniflorin, albiflorin and oxypaeoniflorin after oral gavage of extracts of Radix Paeoniae Rubra and Radix Paeoniae Alba in rats.

Pharmacokinetic properties of albiflorin and paeoniflorin after oral administration of pure compound, Radix Paeoniae alba extract and danggui-shaoyao-san extract to rats.

Studies on metabolism of total glucosides of paeony from Paeoniae Radix Alba in rats by UPLC-Q-TOF-MS/MS.

Protection of H9c2 rat cardiomyoblasts against oxidative insults by total paeony glucosides from Radix Paeoniae Rubrae.

Genetic and chemical characterization of white and red peony root derived from Paeonia lactiflora.

LC-MS/MS determination and pharmacokinetic study of albiflorin and paeoniflorin in rat plasma after oral administration of Radix Paeoniae Alba extract and Tang-Min-Ling-Wan.

Antiallergic effect of the root of Paeonia lactiflora and its constituents paeoniflorin and paeonol.

The novel anti-hyperglycemic effect of Paeoniae radix via the transcriptional suppression of phosphoenopyruvate carboxykinase (PEPCK).

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