NDLI: Quality control and producing areas differentiation of Gardeniae Fructus for eight bioactive constituents by HPLC-DAD-ESI/MS.

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Quality control and producing areas differentiation of Gardeniae Fructus for eight bioactive constituents by HPLC-DAD-ESI/MS.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wu, Xiaoyan Zhou, Yuan Yin, Fangzhou Mao, Chunqin Li, Lin Cai, Baochang Lu, Tulin
Spatial Coverage	China
Description	Author Affiliation: Wu X ( College of Pharmaceutical Science, Nanjing University of Chinese Medicine, Nanjing, PR China.); Zhou Y ( College of Pharmaceutical Science, Nanjing University of Chinese Medicine, Nanjing, PR China.); Yin F ( College of Pharmaceutical Science, Nanjing University of Chinese Medicine, Nanjing, PR China); Mao C ( The Key Research Laboratory of Chinese Medicine Processing of Jiangsu Province, Nanjing University of Chinese Medicine, Nanjing, PR China.); Li L ( College of Pharmaceutical Science, Nanjing University of Chinese Medicine, Nanjing, PR China); Cai B ( College of Pharmaceutical Science, Nanjing University of Chinese Medicine, Nanjing, PR China); Lu T ( College of Pharmaceutical Science, Nanjing University of Chinese Medicine, Nanjing, PR China)
Abstract	Gardeniae Fructus (G.Fructus), the fruit of Gardenia jasminoides Ellis (Rubiaceae), is a commonly used traditional Chinese medicine (TCM) that has been used for the treatment of hepatitis, jaundice, hypersonic, diabetes and hematuria. Numerous researches have demonstrated that the major active constituents in G.Fructus were responsible for the majority of medical effects of this fruit and their quantification were important for the quality control of G.Fructus. However, in the current quality control standard, only geniposide was used as characteristic marker of G.Fructus, which could not reflect the overall quality of this fruit. In order to identify more chemical makers for improving the quality control standard and evaluate producing areas differentiation of G.Fructus, in the present study, a novel and sensitive high-performance liquid chromatography-diode array detector coupled to an electrospray tandem mass spectrometer (HPLC-DAD-ESI/MS) was developed for the simultaneous determination of 8 major constituents, including geniposidic acid (1), chlorogenic acid (2), genipin-1-ß-gentiobioside (3), geniposide (4), genipin (5), rutin (6), crocin-1 (7), crocin-2 (8) in G.Fructus. Moreover, chemometric analysis techniques with principal component constituent analysis (PCA) and cluster analysis (CA) involved were introduced in statistical analysis of 8 investigated constituents in the 34 batches samples to discriminate the samples from different producing areas. The results indicated that the contents of the 8 major bioactive constituents in G.Fructus varied significantly among different producing areas. From results of the loading plot from PCA analysis, genipin-1-ß-gentiobioside may have more influence in discriminating the sample from different producing areas, and which was found to be the most abundant bioactive component besides geniposide in all the 34 batches samples, suggesting that it should be added as chemical marker for further investigation on the pharmacological actions and the quality control of G.Fructus.
File Format	HTM / HTML
ISSN	09447113
Issue Number	4
Volume Number	21
e-ISSN	1618095X
Journal	Phytomedicine
Language	English
Publisher	Elsevier
Publisher Date	2014-03-15
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Complementary Therapies Gardenia Chemistry China Chromatography, High Pressure Liquid Fruit Plant Extracts Standards Principal Component Analysis Quality Control Reference Standards Spectrometry, Mass, Electrospray Ionization Comparative Study Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Molecular Medicine Pharmacology Complementary and Alternative Medicine Pharmaceutical Science

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