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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Svensson, Camilla I. Medicherla, Satyanarayana Malkmus, Shelle Jiang, Yebin Ma, Jing Y. Kerr, Irena Brainin-Mattos, Josue Powell, Harry C. Luo, Z. David Chakravarty, Sarvajit Dugar, Sundeep Higgins, Linda S. Protter, Andrew A. Yaksh, Tony L. |
| Description | Country affiliation: United States Author Affiliation: Svensson CI ( Department of Anesthesiology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0818, USA. csvensson@ucsd.edu) |
| Abstract | The focus of this work was to examine the potential role of p38 mitogen activated protein kinase (p38) in a mouse model of bone cancer (osteosarcoma) pain. To generate osteosarcoma and sham animals, osteosarcoma cells or medium were injected into the medullary canal of the femur. Initially, ipsilateral tactile allodynia was observed in both groups, but by 12 days post-surgery, thresholds in the sham group returned towards baseline while hypersensitivity in the osteosarcoma group lasted throughout the study. An increase in phosphorylated p38 was detected by western blotting in dorsal root ganglia (DRG) and spinal cord day 14 after surgery. Immunohistochemistry showed that p38 was phosphorylated in DRG and spinal dorsal horn neurons at this time point. Two doses of a selective p38 inhibitor, SCIO-469, were administered in the chow starting 5 days post-surgery and continued throughout the study. Treatment with SCIO-469 led to a decrease in osteosarcoma-induced clinical score but had no effect on the allodynia. Bone erosion and tumor growth were also examined but no significant reduction of bone erosion or tumor growth was observed in the SCIO-469 treated mice. These data suggest that the p38 signaling pathway does not play a major role in bone cancer-mediated pain. |
| File Format | HTM / HTML |
| ISSN | 00913057 |
| Issue Number | 4 |
| Volume Number | 90 |
| e-ISSN | 18735177 |
| Journal | Pharmacology Biochemistry and Behavior |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-10-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Behavioral Sciences Discipline Biochemistry Discipline Pharmacology Bone Neoplasms Complications Enzymology Enzyme Inhibitors Therapeutic Use Indoles Osteosarcoma Pain Etiology P38 Mitogen-activated Protein Kinases Physiology Animals Behavior, Animal Drug Effects Body Weight Cell Line, Tumor Eating Enzyme Activation Ganglia, Spinal Immunohistochemistry Male Mice Mice, Inbred C3h Neoplasm Transplantation Drug Therapy Pain Measurement Sensory Thresholds Tomography, X-ray Computed Vocalization, Animal Antagonists & Inhibitors Journal Article Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biological Psychiatry Behavioral Neuroscience Biochemistry Clinical Biochemistry Toxicology Pharmacology |
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