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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Perez, Gydmer A. Haney, Margaret Foltin, Richard W. Hart, Carl L. |
| Description | Country affiliation: United States Author Affiliation: Perez GA ( Division on Substance Abuse, New York State Psychiatric Institute, New York, NY 10032, USA.) |
| Abstract | In a limited number of studies modafinil has been shown to decrease food intake by laboratory animals and humans. The present study represents a secondary data analysis, in which the effects of modafinil on several measures of food intake were determined in humans living in a residential laboratory during simulated shift work. During this 23-day study, a wide selection of food items and beverages were freely available. During this double-blind, within-participant study, volunteers (N = 11) received oral modafinil dose (0, 200, or 400 mg) 1 h after waking for three consecutive days under two shift conditions: day shift and night shift. Shifts alternated three times during the study, and shift conditions were separated by an 'off' day. Modafinil (200, 400 mg) dose-dependently decreased total caloric intake by approximately 18% and approximately 38%, respectively, regardless of shift condition, without selectively altering the proportion of total calories derived from carbohydrate, fat and protein. Ratings of 'Hungry' were also significantly decreased by both active doses, but only immediately before the lunch break period. In addition, tolerance to the anorexic effects of modafinil was not apparent, as these effects remained stable across the three days of modafinil dosing. These findings show that modafinil produced clear reductions in food intake and suggest that future prospective studies should examine the drug in obese participants. |
| File Format | HTM / HTML |
| ISSN | 00913057 |
| Issue Number | 4 |
| Volume Number | 90 |
| e-ISSN | 18735177 |
| Journal | Pharmacology Biochemistry and Behavior |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-10-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Behavioral Sciences Discipline Biochemistry Discipline Pharmacology Benzhydryl Compounds Pharmacology Central Nervous System Stimulants Circadian Rhythm Physiology Eating Drug Effects Hunger Adult Data Interpretation, Statistical Dose-response Relationship, Drug Psychology Energy Intake Female Humans Male Research Design Journal Article Research Support, N.i.h., Extramural |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biological Psychiatry Behavioral Neuroscience Biochemistry Clinical Biochemistry Toxicology Pharmacology |
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