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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rerksuppaphol, Sanguansak Rerksuppaphol, Lakkana |
| Spatial Coverage | Thailand |
| Description | Country affiliation: Thailand Author Affiliation: Rerksuppaphol S ( Department of Pediatrics, Srinakharinwirot University, NakornNayok, Thailand. sanguansak_r@hotmail.com) |
| Abstract | BACKGROUND: The common cold is responsible for the largest proportion of school and work absenteeism and causes a huge economic burden. None of the current interventions is greatly effective for prevention. Our aim was to assess the efficacy of a two-strain combination probiotic for prevention of common cold symptoms in healthy schoolchildren. METHODS: A double-blind randomized controlled trial was performed during the winter season in a public school of central Thailand. Children, aged 8-13 years, were randomized to receive either a two-strain combination probiotic (Lactobacillus acidophilus and Bifidobacterium bifidum) or placebo given twice a day for 3 months. The primary outcome was any symptom of cold during the 3-month study period while vomiting, diarrhea, use of antibiotics, school absence due to any cause, school absence due to cold and duration of all symptoms were secondary outcomes. RESULTS: Of the 40 children in each group, 31 (77%) in the probiotic group, compared to 38 (95%) in the placebo group (P= 0.048), developed at least one symptom of cold. Children in the probiotics group had significantly lower risk of fever, cough, rhinorrhea, school absence and school absence related to common cold compared to children in the placebo group. There was no impact on diarrhea and vomiting. CONCLUSION: A two-strain probiotic combination given twice a day for 3 months was able to reduce the symptoms of the common cold and school absenteeism in schoolchildren. |
| File Format | HTM / HTML |
| ISSN | 13288067 |
| Issue Number | 5 |
| Volume Number | 54 |
| e-ISSN | 1442200X |
| Journal | Pediatrics International |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2012-10-01 |
| Publisher Place | Australia |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pediatrics Bifidobacterium Common Cold Prevention & Control Lactobacillus Acidophilus Probiotics Administration & Dosage Adolescent Child Drug Therapy Double-blind Method Female Humans Male Population Thailand Treatment Outcome Journal Article Randomized Controlled Trial Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pediatrics, Perinatology and Child Health |
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