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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | McNeal-Davidson, Ariane Fournier, Anne Spigelblatt, Linda Saint-Cyr, Claire Mir, Thomas S. Nir, Amiram Dallaire, Frédéric Cousineau, Jocelyne Delvin, Edgard Dahdah, Nagib |
| Description | Country affiliation: Canada Author Affiliation: McNeal-Davidson A ( Division of Pediatric Cardiology, Department of Pediatrics, Sainte-Justine University Hospital Center, University of Montreal, Quebec, Canada.) |
| Abstract | BACKGROUND: The aim of the present study was to investigate the diagnostic value of the N-terminal B-type natriuretic peptide (NT-proBNP) in acute Kawasaki disease (KD) given that the clinical criteria and the current basic laboratory tests lack the necessary specificity for accurate diagnosis. METHODS: Basic biological tests and serum NT-proBNP levels obtained from acute KD patients were compared to that of febrile controls. NT-proBNP was considered abnormal based on the following definitions: above a cut-off determined on receiver operator characteristic (ROC) analysis, above the upper limit for age, or above 2 SD calculated from healthy children. Analyses were also performed for KD cases with complete or incomplete criteria combined and separately. RESULTS: There were 81 patients and 49 controls aged 3.60 ± 2.77 versus 4.25 ± 3.88 years (P= 0.69). ROC analysis yielded significant area under the curve for NT-proBNP. The sensitivity, specificity, positive and negative predictive values were 70.4-88.9%, 69.4-91.8%, 82.8-93.4%, and 65.2-79.1%. The odds ratios based on NT-proBNP definitions varied between 18.13 (95% confidence interval [CI]: 7.21-45.57), 20.82 (95%CI: 8.18-53.0), and 26.71 (95%CI: 8.64-82.57; P < 0.001). Results were reproducible for cases with complete or incomplete criteria separately. CONCLUSION: NT-proBNP is a reliable marker for the diagnosis of KD. Prospective clinical studies with emphasis on NT-proBNP in a diagnostic algorithm are needed. |
| File Format | HTM / HTML |
| ISSN | 13288067 |
| Issue Number | 5 |
| Volume Number | 54 |
| e-ISSN | 1442200X |
| Journal | Pediatrics International |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2012-10-01 |
| Publisher Place | Australia |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pediatrics Mucocutaneous Lymph Node Syndrome Diagnosis Natriuretic Peptide, Brain Blood Peptide Fragments Biological Markers Child Child, Preschool Female Humans Infant Male Predictive Value Of Tests Prospective Studies Roc Curve Sensitivity And Specificity Journal Article Multicenter Study |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pediatrics, Perinatology and Child Health |
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