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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Cañadas, Israel Taus, Álvaro Villanueva, Xavier Arpí, Oriol Pijuan, Lara Rodríguez, Yara Menéndez, Silvia Mojal, Sergi Rojo, Federico Albanell, Joan Rovira, Ana Arriola, Edurne |
| Description | Author Affiliation: Cañadas I ( Cancer Research Program, IMIM (Hospital del Mar Research Institute), Barcelona, Spain. Electronic address: icanadas@imim.es.); Taus Á ( Oncology Department, Hospital del Mar, Barcelona, Spain.); Villanueva X ( Oncology Department, Hospital del Mar, Barcelona, Spain.); Arpí O ( Cancer Research Program, IMIM (Hospital del Mar Research Institute), Barcelona, Spain.); Pijuan L ( Pathology Department, Hospital del Mar, Barcelona, Spain.); Rodríguez Y ( Cancer Research Program, IMIM (Hospital del Mar Research Institute), Barcelona, Spain.); Menéndez S ( Cancer Research Program, IMIM (Hospital del Mar Research Institute), Barcelona, Spain.); Mojal S ( Consulting Service on Methodology for Biomedical Research, IMIM, Barcelona, Spain.); Rojo F ( Pathology Department, IIS-Fundación Jiménez Díaz, Madrid, Spain.); Albanell J ( Cancer Research Program, IMIM (Hospital del Mar Research Institute), Barcelona, Spain); Rovira A ( Cancer Research Program, IMIM (Hospital del Mar Research Institute), Barcelona, Spain); Arriola E ( Cancer Research Program, IMIM (Hospital del Mar Research Institute), Barcelona, Spain) |
| Abstract | BACKGROUND: Small cell lung cancer (SCLC) is a highly lethal disease due to its chemorefractory nature after initial treatment. Angiogenesis plays an important role in tumor growth, metastasis and chemoresistance. We hypothesized that angiogenesis could predict chemoresistance in SCLC patients and be potentially a therapeutic target in this disease. METHODS: Serum samples from forty-three SCLC patients were prospectively obtained at diagnosis, response evaluation and progression. Angiogenesis-related cytokines (Angiopoietin-2, VEGF-A, C and D) were simultaneously quantified by Luminex Technology. Clinical data were prospectively recorder. RESULTS: Significantly higher concentration of angiogenesis-related cytokines were found in SCLC patients at diagnosis compared to healthy volunteers. High baseline serum concentration of Angiopoietin-2 (sAngiopoietin-2) were associated with a worse overall survival (p=0.006) and remained independently associated with survival in the multivariate analysis (p=0.008). In addition, sAngiopoietin-2 significantly increased at progression when compared to baseline. CONCLUSION: These data provide novel evidence on a role of sAngiopoietin-2 in the adverse clinical behavior of SCLC and could be a potential therapeutic target in this disease. |
| File Format | HTM / HTML |
| ISSN | 01695002 |
| Issue Number | 2 |
| Volume Number | 90 |
| e-ISSN | 18728332 |
| Journal | Lung Cancer |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-11-01 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Oncology Angiopoietin-2 Metabolism Lung Neoplasms Pathology Small Cell Lung Carcinoma Aged Disease Progression Female Humans Male Middle Aged Neovascularization, Pathologic Prognosis Vascular Endothelial Growth Factor A Journal Article Observational Study Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine Cancer Research Oncology |
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