NDLI: Recurrent herpetic stromal keratitis in mice, a model for studying human HSK.

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Recurrent herpetic stromal keratitis in mice, a model for studying human HSK.

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Recurrent herpetic stromal keratitis in mice, a model for studying human HSK.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Morris, Jessica Stuart, Patrick M. Rogge, Megan Potter, Chloe Gupta, Nipun Yin, Xiao-Tang
Description	Author Affiliation: Morris J ( Department of Ophthalmology, Saint Louis University.)
Abstract	Herpetic eye disease, termed herpetic stromal keratitis (HSK), is a potentially blinding infection of the cornea that results in over 300,000 clinical visits each year for treatment. Between 1 and 2 percent of those patients with clinical disease will experience loss of vision of the infected cornea. The vast majority of these cases are the result of reactivation of a latent infection by herpes simplex type I virus and not due to acute disease. Interestingly, the acute infection is the model most often used to study this disease. However, it was felt that a recurrent model of HSK would be more reflective of what occurs during clinical disease. The recurrent animal models for HSK have employed both rabbits and mice. The advantage of rabbits is that they experience reactivation from latency absent any known stimulus. That said, it is difficult to explore the role that many immunological factors play in recurrent HSK because the rabbit model does not have the immunological and genetic resources that the mouse has. We chose to use the mouse model for recurrent HSK because it has the advantage of there being many resources available and also we know when reactivation will occur because reactivation is induced by exposure to UV-B light. Thus far, this model has allowed those laboratories using it to define several immunological factors that are important to this disease. It has also allowed us to test both therapeutic and vaccine efficacy.
File Format	HTM / HTML
e-ISSN	1940087X
DOI	10.3791/4276
Journal	Journal of Visualized Experiments
Issue Number	70
Language	English
Publisher	MyJove Corp.
Publisher Date	2012-12-18
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Physical Sciences Discipline Life Sciences Discipline Medicine Disease Models, Animal Herpes Simplex Virology Herpesvirus 1, Human Physiology Keratitis, Herpetic Animals Cercopithecus Aethiops Mice Mice, Inbred C57bl Recurrence Vero Cells Virus Activation Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Video-audio Media
Content Type	Text
Resource Type	Article

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