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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ma, Zhe Liu, Cun Deng, Biping Dong, Shaogang Tao, Guowei Zhan, Xinfeng Wang, Chuner Liu, Shaoping Qu, Xun |
| Description | Country affiliation: China Author Affiliation: Ma Z ( Department of Ultrasound Basic Medicine, Qilu Hospital, Shandong University, Shandong Province, China.) |
| Abstract | AIM: To detect the distinct proteins in amniotic fluid (AF) between nervous system malformations fetuses and normal fetuses. MATERIAL AND METHODS: Surface-enhanced laser desorption-ionization/time-of-flight mass spectrometry was used to characterize AF peptides in AF between nervous system malformations fetuses and normal fetuses. WCX2 protein chips were used to characterize AF peptides in AF. Protein chips were examined in a PBSIIC protein reader, the protein profiling was collected by ProteinChip software version 3.1 (Ciphergen Biosystems, Fremont, CA, USA) and analyzed by Biomarker Wizard software (Ciphergen Biosystems). Nine distinct proteins were identified in AF between nervous system malformations fetuses and normal fetuses. RESULTS: Compared with the control group, three proteins with m/z 4967.5 Da, 5258.0 Da, and 11,717.0 Da were down-regulated, and six proteins with m/z 2540.4 Da, 3107.1 Da, 3396.8 Da, 4590.965 Da, 5589.2 Da and 6429.4 Da up-regulated in nervous system malformations fetuses. CONCLUSION: The results suggest that there are distinct proteins in protein profiling of AF between nervous system malformations fetuses and normal fetuses. |
| File Format | HTM / HTML |
| ISSN | 13418076 |
| Issue Number | 6 |
| Volume Number | 36 |
| e-ISSN | 14470756 |
| Journal | Journal of Obstetrics and Gynaecology Research |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2010-12-01 |
| Publisher Place | Australia |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Obstetrics Discipline Gynecology Amniotic Fluid Metabolism Nervous System Malformations Diagnosis Spectrometry, Mass, Matrix-assisted Laser Desorption-ionization Adult Biological Markers Databases, Protein Female Fetal Diseases Humans Peptide Mapping Pregnancy Prenatal Diagnosis Reproducibility Of Results Young Adult Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Obstetrics and Gynecology |
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