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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rani, Neerja Dhingra, Renu Arya, Dharamveer Singh Kalaivani, Mani Bhatla, Neerja Kumar, Rani |
| Description | Country affiliation: India Author Affiliation: Rani N ( Departments of Anatomy Pharmacology Biostatistics Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.) |
| Abstract | AIM: The present study aimed to evaluate and compare the placental variables of oxidative stress markers in preeclamptic women. METHODS: A total of 60 placentas were collected. Of these, 30 were obtained from normotensive pregnancies, and 30 from pregnancies with preeclampsia as per International Society for the Study of Hypertension in Pregnancy (ISSHP) criteria. Each placental tissue was analyzed for levels of pro-oxidant (malondialdehyde) and antioxidants (glutathione and superoxide dismutase) using the standard enzymatic assays. RESULTS: Malondialdehyde levels were significantly higher (12.21 ± 4.1 versus 4.7 ± 2.1 nmol/g tissue, P < 0.0001) and glutathione (GSH) levels were significantly lower (0.46 ± 0.37 versus 1.03 ± 0.43 µmol/g tissue, P < 0.0001) in the placentas of preeclamptic women when compared to those of normal pregnancies. Though not statistically significant, decreases in superoxide dismutase levels were observed in placentas of preeclamptic women (4.14 ± 2.25 versus 5.22 ± 2.0 units/mg tissue protein, P < 0.055). Receiver operator characteristic curve analysis of malondialdehyde revealed a sensitivity of 87% and specificity of 87%, at a cutoff value 6.5 nmol/g. Similarly, GSH had a sensitivity of 77% and a specificity of 77% at a cutoff value 0.62 µmol/g. CONCLUSION: The present study demonstrated that increased placental lipid peroxidation and decreased levels of antioxidants may play an important role in the pathogenesis of preeclampsia. These findings are suggestive of involvement of oxidative stress markers in preeclamptic patients. |
| File Format | HTM / HTML |
| ISSN | 13418076 |
| Issue Number | 6 |
| Volume Number | 36 |
| e-ISSN | 14470756 |
| Journal | Journal of Obstetrics and Gynaecology Research |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2010-12-01 |
| Publisher Place | Australia |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Obstetrics Discipline Gynecology Antioxidants Metabolism Oxidative Stress Placenta Pre-eclampsia Adult Biological Markers Case-control Studies Female Glutathione Humans Malondialdehyde Pregnancy Roc Curve Superoxide Dismutase Comparative Study Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Obstetrics and Gynecology |
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