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Importance of optimal local uterine blood flow for implantation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Nakamura, Hitomi Hosono, Takayoshi Minato, Kenji Hamasaki, Toshimitsu Kumasawa, Keiichi Kimura, Tadashi
Description	Author Affiliation: Nakamura H ( Departments of 1Obstetrics and Gynecology.)
Abstract	AIMS: The aim of this study was to determine whether uterine blood flow is an effective parameter to anticipate uterine receptivity. MATERIAL AND METHODS: The local uterine blood flow was measured in the endometrium and on the outside of the uterus in mice during the early stage of pregnancy and an implantation failure mouse model using transient and local suppression of signal transducer and activator of transcription-3 activity during implantation. RESULTS: The local uterine blood flow was dramatically increased after mating and was decreased towards the time of implantation. The local uterine blood flow at 2.5 days post-coitus in signal transducer and activator of transcription-3 decoy transferred mice was significantly higher than in control mice. However, the range of individual values was too wide to find a cut-off point. CONCLUSIONS: It is necessary to decrease local uterine blood flow after ovulation to prepare the opening implantation window. The optimal local uterine blood flow is regulated by time events during pregnancy. The range of individual values of uterine blood flow is wide using a laser Doppler blood flow meter. This parameter itself may not be an appropriate parameter to evaluate the prospect of uterine receptivity.
File Format	HTM / HTML
ISSN	13418076
Issue Number	6
Volume Number	40
e-ISSN	14470756
Journal	Journal of Obstetrics and Gynaecology Research
Language	English
Publisher	Wiley
Publisher Date	2014-06-01
Publisher Place	Australia
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Obstetrics Discipline Gynecology Embryo Implantation Pregnancy, Animal Physiology Uterus Blood Supply Animals Female Mice, Inbred Icr Pregnancy Regional Blood Flow Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Obstetrics and Gynecology

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Up-regulated monoamine oxidase in the mouse uterus during the peri-implantation period.

In vivo hatching phenomenon of mouse blastocysts during implantation.

Importance of optimal local uterine blood flow for implantation.

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