NDLI: Clinical analysis of 65 cases of hyperemesis gravidarum with gestational transient thyrotoxicosis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sun, Shuiya Qiu, Xia Zhou, Jiaqiang
Spatial Coverage	China
Description	Country affiliation: China Author Affiliation: Sun S ( Department of Endocrinology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China)
Abstract	AIM: We investigated thyroid function and the impact of gestational transient thyrotoxicosis (GTT) on pregnancy outcome in patients with hyperemesis gravidarum (HG; n = 143) who were hospitalized for rehydration. METHODS: Serum thyroid-stimulating hormone (TSH), free T3 (FT3), free T4 (FT4), thyroid globulin antibody (TgAb), thyroid peroxidase antibody (TPOAb) and hCG were measured after admission. RESULTS: The total prevalence of thyrotoxicosis in HG was 48.3%; GTT was the main form (45.5%). The total incidence of GTT increased significantly if serum hCG was more than 80,000 IU/L, subclinical GTT if serum hCG was 80,000-140,000 IU/L and clinical GTT if serum hCG was more than 180,000 IU/L. GTT did not require antithyroid therapy. The course of TSH, FT3 and FT4 were followed in 34 cases of GTT; thyroid function normalized by the second trimester. Of 65 patients with GTT, two underwent abortions due to unplanned pregnancies, two delivered prematurely and two infants had macrosomia. There were no other complications. All newborns (n = 63) of mothers with GTT had normal TSH levels. CONCLUSION: GTT is common in HG. The severity of GTT is related to serum hCG levels. In patients with HG and GTT, thyroid function normalized by the second trimester without antithyroid treatment. GTT did not affect pregnancy outcomes.
File Format	HTM / HTML
ISSN	13418076
Issue Number	6
Volume Number	40
e-ISSN	14470756
Journal	Journal of Obstetrics and Gynaecology Research
Language	English
Publisher	Wiley
Publisher Date	2014-06-01
Publisher Place	Australia
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Obstetrics Discipline Gynecology Hyperemesis Gravidarum Complications Thyroid Hormones Blood Thyrotoxicosis Adult China Epidemiology Chorionic Gonadotropin Female Humans Incidence Pregnancy Pregnancy Outcome Retrospective Studies Young Adult Journal Article
Content Type	Text
Resource Type	Article
Subject	Obstetrics and Gynecology

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