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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lin, Hsin-Yi Yeh, Chih-Tsung |
| Description | Country affiliation: Taiwan Author Affiliation: Lin HY ( Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Sec 3, Zhongxiao E. Rd, 106, Taipei, Taiwan. hbrunken@ntut.edu.tw) |
| Abstract | To prevent fibrous encapsulation of implants, measures are taken to suppress inflammatory reactions around them. Sustained anti-inflammatory drug release from the scaffolds can potentially be a way to reduce inflammation around these implants. Alginate-crosslinked chitosan is often used to make biocompatible tissue engineered scaffolds. However, there is a lack of quantitative studies on the drug delivery properties of alginate-crosslinked chitosan scaffolds. For this study, chitosan, crosslinked with different concentrations of alginate, was made into porous scaffolds. Infrared and thermal gravimetric analyses showed polyelectrolyte complex formation between chitosan and alginate units. The alginate-crosslinked chitosan scaffolds were more hydrophilic, showed less swelling, had lower pentoxifylline (PTX) release efficacies, were more favorable for initial cell attachment, and were mechanically stronger and more resistant to enzymatic degradation when compared to non-crosslinked chitosan scaffolds. The differences became more significant as the concentrations of chitosan and alginate increased. Furthermore, in vitro tests showed that when PTX was slowly released from the scaffolds, it became more effective in suppressing the production of TNF-alpha and IL-6 by stimulated macrophage cells. |
| File Format | HTM / HTML |
| ISSN | 09574530 |
| Issue Number | 5 |
| Volume Number | 21 |
| e-ISSN | 15734838 |
| Journal | Journal of Materials Science: Materials in Medicine |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2010-05-01 |
| Publisher Place | United States |
| Access Restriction | Subscribed |
| Subject Keyword | Discipline Biomedical Engineering Drug Delivery Systems Tissue Scaffolds Chemistry Alginates Chitosan Pharmacology Delayed-action Preparations Glucuronic Acid Hexuronic Acids Interleukin-6 Pentoxifylline Tumor Necrosis Factor-alpha Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomaterials Biophysics Bioengineering Biomedical Engineering |
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