NDLI: Tannic acid incorporation in chitosan-based microparticles and in vitro controlled release.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Aelenei, Neculai Popa, Marcel Ionel Novac, Ovidiu Lisa, Gabriela Balaita, Lacramioara
Description	Country affiliation: Romania Author Affiliation: Aelenei N ( Chemical Engineering Department, Chemical Engineering and Environment Protection Faculty, Technical University of Iasi, Iasi, Romania. naelenei@ch.tuiasi.ro)
Abstract	Chitosan, a natural polycationic polysaccharide, was coupled with two polyanionic polymers: Na-alginate and carboxymethylcellulose (CMC) and with tannic acid (TA) obtaining three species of self-assembled complexes: chitosan/alginate/TA (sample 1), chitosan/TA (sample 2) and chitosan/CMC/TA (sample 3). The microparticle formation was achieved by dropwise addition of one solution into other by using a coaxial airflow sprayer. These systems were characterized with regard to particle size distribution, thermal stability, tannic acid entrapment efficiency. Sample 2 showed quite a different behavior compared to the other two samples; the particle diameter is located in the nanometric region, the quantity of incorporated tannic acid is higher than in the other two samples and the material shows better thermal stability. The release of tannic acid from these complexes was studied in water (pH = 5.89), phosphates buffer (pH = 7.04) and acetate buffer (pH = 4.11). These studies revealed two distinct periods in tannic acid delivery process: an initial period, varying between 4 and 10 h, characterized by a high release rate with a delivered tannic acid amount of approximately 80% of the incorporated polyphenol and a second period, which starts after 20 to 30 h of delivery and it ends after approximately 120 h, when the release process takes place with low and constant rate and the kinetic curve is linear--characteristic for a zero order kinetic.
File Format	HTM / HTML
ISSN	09574530
Issue Number	5
Volume Number	20
e-ISSN	15734838
Journal	Journal of Materials Science: Materials in Medicine
Language	English
Publisher	Springer
Publisher Date	2009-05-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Biomedical Engineering Biocompatible Materials Chemistry Chitosan Drug Carriers Tannins Administration & Dosage Alginates Delayed-action Preparations Glucuronic Acid Hexuronic Acids Hydrogen-ion Concentration In Vitro Techniques Materials Testing Microspheres Particle Size Spectroscopy, Fourier Transform Infrared Thermogravimetry Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

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