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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Shrivastava, Kalpana Gonzalez, Pau Acarin, Laia |
| Description | Country affiliation: Spain Author Affiliation: Shrivastava K ( Medical Histology, Institute of Neuroscience, Department of Cell Biology, Physiology, and Immunology, Universitat Autonoma Barcelona, Bellaterra 08193, Barcelona, Spain. kalpana.shrivastava@uab.cat) |
| Abstract | The CD200/CD200R inhibitory immune ligand–receptor system regulates microglial activation/quiescence in adult brain. Here, we investigated CD200/CD200R at different stages of postnatal development, when microglial maturation takes place. We characterized the spatiotemporal, cellular, and quantitative expression pattern of CD200 and CD200R in the developing and adult C57/BL6 mice brain by immunofluorescent labeling and Western blotting. CD200 expression increased from postnatal day 1 (P1) to P5–P7, when maximum levels were found, and decreased to adulthood. CD200 was located surrounding neuronal bodies, and very prominently in cortical layer I, where $CD200^{+}$ structures included glial fibrillary acidic protein $(GFAP)^{+}$ astrocytes until P7. In the hippocampus, CD200 was mainly observed in the hippocampal fissure, where $GFAP^{+}/CD200^{+}$ astrocytes were also found until P7. $CD200^{+}$ endothelium was seen in the hippocampal fissure and cortical blood vessels, notably from P14, showing maximum vascular CD200 in adults. $CD200R^{+}$ cells were a population of ameboid/pseudopodic $Iba1^{+}$ microglia/macrophages observed at all ages, but significantly decreasing with increasing age. $CD200R^{+}/Iba1^{+}$ macrophages were prominent in the pial meninges and ventricle lining, mainly at P1–P5. $CD200R^{+}/Iba1^{+}$ perivascular macrophages were observed in cortical and hippocampal fissure blood vessels, showing maximum density at P7, but being prominent until adulthood. $CD200R^{+}/Iba1^{+}$ ameboid microglia in the cingulum at P1–P5 were the only $CD200R^{+}$ cells in the nervous tissue. In conclusion, the main sites of CD200/CD200R interaction seem to include the molecular layer and pial surface in neonates and blood vessels from P7 until adulthood, highlighting the possible role of the CD200/CD200R system in microglial development and renewal. J. Comp. Neurol. 520:2657–2675, 2012. © 2012 Wiley Periodicals, Inc. |
| File Format | HTM / HTML |
| ISSN | 00219967 |
| Issue Number | 12 |
| Volume Number | 520 |
| e-ISSN | 10969861 |
| Journal | Journal of Comparative Neurology |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2012-08-15 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Neurology Antigens, Cd Metabolism Brain Chemistry Immunology Membrane Glycoproteins Neural Inhibition Aging Genetics Animals Animals, Newborn Antibody Specificity Antigen-antibody Reactions Female Hippocampus Blood Supply Growth & Development Macrophages Cytology Male Mice Mice, Inbred C57bl Microglia Neocortex Neurogenesis Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience |
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