NDLI: A randomized, double blind, placebo controlled clinical trial of the preoperative use of ketamine for reducing inflammation and pain after thoracic surgery.

Please wait, while we are loading the content...

Year: 2017 Volume: 31

Year: 2016 Volume: 30

Year: 2015 Volume: 29

Year: 2014 Volume: 28

Year: 2013 Volume: 27

Year: 2012 Volume: 26

Year: 2011 Volume: 25

Year: 2011 Volume: 25 Issue: 6

Year: 2011 Volume: 25 Issue: 5

Successful treatment of acute respiratory distress syndrome after hysterectomy for life-threatening atonic bleeding by inhaled nitric oxide.

Combined lumbar plexus and sciatic nerve block for hip fracture surgery in a patient with severe aortic stenosis.

Tracheomalacia after reoperation for an adenomatous goiter located in a unique position.

Giant coronary artery aneurysm with coronary arteriovenous fistula draining into the coronary sinus.

Association between cerebrovascular carbon dioxide reactivity and postoperative short-term and long-term cognitive dysfunction in patients with diabetes mellitus

Adjuvant dexamethasone with bupivacaine prolongs the duration of interscalene block: a prospective randomized trial.

Direct assessment of the antioxidant properties of midazolam by electron spin resonance spectroscopy.

Suspected recurrent anaphylaxis in different forms during general anesthesia: implications for Kounis syndrome.

Prognostic factors associated with mortality in patients undergoing emergency surgery for abdominal aortic aneurysms.

Epidural anesthesia with intravenous dexmedetomidine sedation in the successful anesthetic management of MRI-guided focused ultrasound ablation of early prostatic cancer.

Postdural puncture headache following acupuncture.

The role of Certified Registered Nurse Anesthetists in the United States.

Effects of propofol and pentobarbital on calcium concentration in presynaptic boutons on a rat hippocampal neuron

Flurbiprofen axetil enhances analgesic effect of fentanyl associated with increase in ß-endorphin levels.

Comparison of postoperative pharyngeal morbidity using the Macintosh laryngoscope or AirWay Scope after mastectomy.

Ketamine-midazolam anesthesia for an infant with arthrogryposis multiplex congenita: a case with decreased myocardial contractility.

Backboard insertion in the operating table increases chest compression depth: a manikin study.

Influence of tidal volume for stroke volume variation to predict fluid responsiveness in patients undergoing one-lung ventilation.

Influence of bupivacaine injection dose rate on cardiovascular depression, subsequent hemodynamic course, and related bupivacaine plasma levels in piglets.

Multilevel nerve stimulator-guided paravertebral block as a sole anesthetic technique for breast cancer surgery in morbidly obese patients.

Epidural infusions versus transversus abdominis plane (TAP) block infusions: retrospective study.

Accidental epidural injection of rocuronium.

Effects of aminophylline on cognitive recovery after sevoflurane anesthesia.

Effect of acupuncture on nausea and/or vomiting during and after cesarean section in comparison with ondansetron.

Propofol protects against impairment of learning-memory and imbalance of hippocampal Glu/GABA induced by electroconvulsive shock in depressed rats.

A new modification for safer submental orotracheal intubation.

Effect of flurbiprofen, metoclopramide and droperidol for nausea and emesis during cesarean section under spinal anesthesia.

Fiberoptic-guided tracheal tube placement through the air-Q® Intubating Laryngeal Airway: a performance study in a manikin.

Do we worry about latex allergy during cesarean delivery under spinal anesthesia?

A randomized, double blind, placebo controlled clinical trial of the preoperative use of ketamine for reducing inflammation and pain after thoracic surgery.

Intraoperative reversal of neuromuscular block with sugammadex or neostigmine during extreme lateral interbody fusion, a novel technique for spine surgery.

The effect of patient-controlled intravenous analgesia on postoperative hypokalemia in patients undergoing laparoscopic cholecystectomy.

Statistically significant?

Year: 2011 Volume: 25 Issue: 4

Year: 2011 Volume: 25 Issue: 3

Year: 2011 Volume: 25 Issue: 2

Year: 2011 Volume: 25 Issue: 1

Year: 2010 Volume: 24

Year: 2009 Volume: 23

Year: 2008 Volume: 22

Year: 1997 Volume: 11

Year: 1996 Volume: 10

Year: 1995 Volume: 9

Year: 1994 Volume: 8

Year: 1993 Volume: 7

Year: 1992 Volume: 6

Year: 1989 Volume: 3

A randomized, double blind, placebo controlled clinical trial of the preoperative use of ketamine for reducing inflammation and pain after thoracic surgery.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	D'Alonzo, Richard C. Bennett-Guerrero, Elliott Podgoreanu, Mihai D'Amico, Thomas A. Harpole, David H. Shaw, Andrew D.
Description	Country affiliation: United States Author Affiliation: D'Alonzo RC ( Department of Anesthesiology, Pitt Count Memorial Hospital, Greenville, NC 27858, USA.)
Abstract	PURPOSE: We hypothesized that patients who received ketamine during thoracic surgery would benefit from suppression of the inflammatory cascade, represented by lower interleukin (IL)-6 and C-reactive protein (CRP) plasma levels. METHODS: This study was a randomized, double blind, placebo controlled clinical trial of ketamine in patients undergoing thoracic surgery. The setting was a single university teaching hospital. Forty patients who presented to the preoperative clinic prior to thoracic surgery (20 control, 20 treatment) were randomized to receive either a 0.5 mg/kg ketamine bolus or an equivalent volume of normal saline intravenously prior to chest wall incision. Plasma samples taken prior to induction of anesthesia and at 24 h following surgery were assayed for IL-6 and CRP levels. Verbal pain scores were reported at 4 and 24 h following surgery and at discharge. RESULTS: IL-6 plasma levels did not differ significantly at 24 h for patients receiving ketamine (245 ± 287 pg/ml, mean ± SD) compared to patients who received placebo (269 ± 210 pg/ml), p = 0.39. Additionally, CRP levels at 24 h were not significantly different (8.8 ± 4.5 mg/dl for ketamine, 9.3 ± 5.6 mg/dl for placebo patients), p = 0.37. Finally, verbal pain scores were not significantly different between patient groups at 4 or 24 h, or at discharge. CONCLUSIONS: These findings suggest that the routine use of a single dose of ketamine prior to chest wall incision is not effective at reducing pain or inflammation in thoracic surgery patients at 24 h postoperatively.
File Format	HTM / HTML
ISSN	09138668
Issue Number	5
Volume Number	25
e-ISSN	14388359
Journal	Journal of Anesthesia
Language	English
Publisher	Springer
Publisher Date	2011-10-01
Publisher Place	Japan
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Anesthesiology Analgesics Administration & Dosage Inflammation Drug Therapy Ketamine Pain, Postoperative Thoracic Surgical Procedures Adverse Effects Aged C-reactive Protein Metabolism Double-blind Method Female Humans Blood Interleukin-6 Male Middle Aged Placebos Preoperative Care Methods Clinical Trial Journal Article Randomized Controlled Trial
Content Type	Text
Resource Type	Article
Subject	Anesthesiology and Pain Medicine

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in