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Confocal microscopy study of pertussis toxin and toxoids on CHO-cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tan, Yajun Fleck, Roland A. Asokanathan, Catpagavalli Yuen, Chun-Ting Xing, Dorothy Zhang, Shumin Wang, Junzhi
Description	Country affiliation: China Author Affiliation: Tan Y ( National Institutes for Food and Drug Control)
Abstract	Pertussis toxin in its detoxified form is a major component of all current acellular pertussis vaccines. Here we report the membrane translocation and internalization activities of pertussis toxin and various pertussis toxoids using Chinese hamster ovary cells and confocal microscopy based on indirect immunofluorescence labeling. Chemically detoxified pertussis toxoids were able to translocate/internalize into cells at the concentration about 1,000 times higher than the native toxin. Pertussis toxoids detoxified with different procedures (glutaraldehyde, glutaraldehyde plus formaldehyde, hydrogen peroxide or genetic mutation) showed differences in fluorescence intensity under the same condition, indicating toxoids from different detoxification methods may have different translocation/internalization activities on cells.
File Format	HTM / HTML
ISSN	21645515
e-ISSN	2164554X
Journal	Human Vaccines & Immunotherapeutics
Issue Number	2
Volume Number	9
Language	English
Publisher	Taylor & Francis
Publisher Date	2013-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Immunology Discipline Therapeutics Microscopy, Confocal Pertussis Toxin Metabolism Toxoids Animals Cho Cells Cricetulus Protein Transport Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology Pharmacology

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Confocal microscopy study of pertussis toxin and toxoids on CHO-cells

Confocal microscopy study of pertussis toxin and toxoids on CHO-cells

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