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Impact of rotavirus vaccination in Australian children below 5 years of age: a database study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Pendleton, Annmarie Galic, Maja Clarke, Christopher Ng, Su Peing Ledesma, Emilio Ramakrishnan, Gunasekaran Liu, Yanfang
Spatial Coverage	New South Wales Australian Capital Territory Northern Territory
Description	Author Affiliation: Pendleton A ( GlaxoSmithKline Vaccines Pty Ltd)
Abstract	This study was conducted to assess the impact of administration of two-dose rotavirus (RV) vaccine (RIX4414; GlaxoSmithKline Vaccines) among children aged less than 5 y in three states/territories of Australia. Aggregated and de-identified data on rotavirus gastroenteritis (RVGE) and all-cause gastroenteritis (AGE) from July 1998-June 2009 were obtained from the Australian Institute of Health and Welfare database. The baseline incidence (July 1998-June 2006) of RVGE hospitalizations before RV vaccine introduction in New South Wales (NSW), the Australian Capital Territory (ACT) and the Northern Territory (NT) were 33.75, 42.93 and 288.67 per 10,000 child-years, respectively among children aged 0-11 mo. Following RV vaccine introduction in NSW, the ACT and the NT, incidence of RVGE hospitalizations reduced to 13.06, 17.35 and 47.52 per 10,000 child-years, respectively, during July 2007-June 2008 and 3.87, 8.40 and 122.79 per 10,000 child-years, respectively, during July 2008-June 2009 among children aged 0-11 mo. Reductions in RVGE and AGE were also observed in all children below 5 y of age in NSW and the ACT. Overall reduction in hospitalizations due to RVGE and AGE was observed following RV vaccine introduction into the NIP in Australia.
File Format	HTM / HTML
ISSN	21645515
e-ISSN	2164554X
DOI	10.4161/hv.24831
Journal	Human Vaccines & Immunotherapeutics
Issue Number	8
Volume Number	9
Language	English
Publisher	Taylor & Francis
Publisher Date	2013-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Immunology Discipline Therapeutics Gastroenteritis Epidemiology Prevention & Control Rotavirus Infections Rotavirus Vaccines Immunology Vaccination Utilization Australian Capital Territory Child, Preschool Hospitalization Statistics & Numerical Data Infant Infant, Newborn New South Wales Northern Territory Administration & Dosage Vaccines, Attenuated Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology Pharmacology

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