NDLI: Immunotherapeutic efficiency of a tetravalent Aß1-15 vaccine in APP/PS1 transgenic mice as mouse model for Alzheimer's disease.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Guan, Xiaoying Yang, Junhua Gu, Huaiyu Zou, Juntao Yao, Zhibin
Description	Author Affiliation: Guan X ( Department of Anatomy and Neurobiology)
Abstract	Immunization with synthetic, preaggregated ß-amyloid (Aß) was the first treatment approach able to dramatically reduce brain Aß pathology in Alzheimer's disease (AD) animal models. For the development of a safe vaccine, we investigated whether 4Aß1-15 (four tandem repeats of GPGPG-linked Aß1-15 sequences) had therapeutic effects in the APP/PS1 transgenic mice model of AD. We described the production of anti-Aß antibodies in APP/PS1 mice immunized with 4Aß1-15 mixed with MF59 adjuvant. The anti-Aß antibody concentrations were increased which bound to AD plaques, markedly reduced Aß pathology in transgenic AD mice and levels of intracerebral Aß (soluble and insoluble), whereas increased serum Aß levels. Immunization via 4Aß1-15 (mainly of the IgG1 Class) may induce a non-inflammatory Th2 reaction. Immunohistochemistry analysis of MHC Class II and CD45 revealed that microglial cells were in a less activated state. Of note, 4Aß1-15-immunized mice showed improved acquisition of memory compared with controls in a reference-memory Morris water-maze behavior test. The data identify the novel immunogen 4Aß1-15 as a promising new tool for AD immunotherapy.
File Format	HTM / HTML
ISSN	21645515
e-ISSN	2164554X
DOI	10.4161/hv.24830
Journal	Human Vaccines & Immunotherapeutics
Issue Number	8
Volume Number	9
Language	English
Publisher	Taylor & Francis
Publisher Date	2013-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Immunology Discipline Therapeutics Alzheimer Disease Therapy Amyloid Beta-peptides Administration & Dosage Immunology Immunotherapy Peptide Fragments Adjuvants, Immunologic Pathology Animals Antibodies Blood Brain Physiology Disease Models, Animal Memory Mice Mice, Transgenic Polysorbates Squalene Vaccines, Subunit Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology Pharmacology

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