NDLI: Impact of EGFR mutations and KRAS amino acid substitution on the response to radiotherapy for brain metastasis of non-small-cell lung cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Renaud, Stéphane Schaeffer, Mickaël Voegeli, Anne-Claire Legrain, Michèle Guérin, Eric Meyer, Nicolas Mennecier, Bertrand Quoix, Elisabeth Falcoz, Pierre-Emmanuel Guénot, Dominique Massard, Gilbert Noël, Georges Beau-Faller, Michèle
Description	Country affiliation: France Author Affiliation: Renaud S ( Thoracic Surgery Department, Strasbourg University Hospital, France.); Schaeffer M ( Research Unit EA 3430 & Translational Medicine Federation, Strasbourg University, France.); Voegeli AC ( Statistical Department, Strasbourg University Hospital, France.); Legrain M ( Department of Biochemistry & Molecular Biology, Oncobiology laboratory, Regional Institute of Cancer, Strasbourg University Hospital, France.); Guérin E ( Department of Biochemistry & Molecular Biology, Oncobiology laboratory, Regional Institute of Cancer, Strasbourg University Hospital, France.); Meyer N ( Department of Biochemistry & Molecular Biology, Oncobiology laboratory, Regional Institute of Cancer, Strasbourg University Hospital, France.); Mennecier B ( Statistical Department, Strasbourg University Hospital, France.); Quoix E ( Chest Department, Strasbourg University Hospital, France.); Falcoz PE ( Chest Department, Strasbourg University Hospital, France.); Guénot D ( Thoracic Surgery Department, Strasbourg University Hospital, France.); Massard G ( Research Unit EA 3430 & Translational Medicine Federation, Strasbourg University, France.); Noël G ( Thoracic Surgery Department, Strasbourg University Hospital, France.); Beau-Faller M ( Department of Radiotherapy, Centre Paul Strauss, Strasbourg, France.)
Abstract	BACKGROUND: Our study aimed to evaluate response rate (RR) to brain metastasis radiotherapy (RT), depending on the genomic status of non-small-cell lung cancer. MATERIAL & METHODS: We retrospectively reviewed 1971 non-small-cell lung cancer files of patients with EGFR and KRAS testing and focused on 157 patients who had undergone RT for brain metastasis. RESULTS: A total of 16 patients (10.2%) harbored EGFR mutations (mEGFR) and 45 patients (28.7%) KRAS (mKRAS). In univariate analysis, RR was significantly higher for mEGFR compared with wild-type EGFR/KRAS (odds ratio [OR]: 4.96; p = 0.05) or mKRAS (OR: 1.81; p = 0.03). In multivariate analysis, KRAS G12V or G12C status was associated with both poor RR (OR: 0.1; p < 0.0001) and overall survival (OR: 3.41; p < 0.0001). CONCLUSION: mEGFR are associated with higher RR to brain RT than wild-type EGFR/RAS or mKRAS.
File Format	HTM / HTML
ISSN	14796694
Issue Number	1
Volume Number	12
e-ISSN	17448301
Journal	Future Oncology
Language	English
Publisher	Future Medicine Ltd.
Publisher Date	2016-01-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Brain Neoplasms Radiotherapy Carcinoma, Non-small-cell Lung Proto-oncogene Proteins P21(ras) Genetics Receptor, Epidermal Growth Factor Adult Aged Aged, 80 And Over Amino Acid Substitution Pathology Secondary Disease-free Survival Female Genetic Association Studies Humans Kaplan-meier Estimate Male Middle Aged Mutation Polymorphism, Single Nucleotide Radiation Tolerance Journal Article
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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