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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zahnreich, Sebastian Mayer, Arnulf Loquai, Carmen Grabbe, Stephan Schmidberger, Heinz |
| Description | Country affiliation: Germany Author Affiliation: Zahnreich S ( Department of Radiation Oncology & Radiotherapy, University Medical Center Johannes Gutenberg University Mainz, Germany.); Mayer A ( Department of Radiation Oncology & Radiotherapy, University Medical Center Johannes Gutenberg University Mainz, Germany.); Loquai C ( Department of Dermatology, University Medical Center Johannes Gutenberg University Mainz, Germany.); Grabbe S ( Department of Dermatology, University Medical Center Johannes Gutenberg University Mainz, Germany.); Schmidberger H ( Department of Radiation Oncology & Radiotherapy, University Medical Center Johannes Gutenberg University Mainz, Germany.) |
| Abstract | The introduction of small molecule BRAF(V600) kinase inhibitors represents a milestone in the targeted therapy of patients with metastatic melanoma by a significant increase in therapeutic efficacy in terms of overall and progression-free survival compared with conventional chemotherapy. Beside BRAF(V600) inhibitor treatment, radiotherapy is a further mainstay for the therapy of metastatic melanoma and thus a concomitant or sequential application of BRAF(V600) inhibitors and radiotherapy is inevitable. Recent reports show a significant radiosensitization of the irradiated healthy tissue in patients with melanoma after the combination of radiotherapy and BRAF(V600) inhibitors, evoking concern in clinical practice. We review interactions of BRAF(V600) inhibitors and radiation with regard to antitumor effects and an increased radiotoxicity in the healthy tissue. |
| File Format | HTM / HTML |
| ISSN | 14796694 |
| Issue Number | 1 |
| Volume Number | 12 |
| e-ISSN | 17448301 |
| Journal | Future Oncology |
| Language | English |
| Publisher | Future Medicine Ltd. |
| Publisher Date | 2016-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Subscribed |
| Subject Keyword | Discipline Oncology Melanoma Drug Therapy Radiotherapy Proto-oncogene Proteins B-raf Genetics Radiation Tolerance Drug Effects Combined Modality Therapy Adverse Effects Humans Pathology Mutation Protein Kinase Inhibitors Therapeutic Use Antagonists & Inhibitors Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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