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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Al-Marrawi, Mhd Yaser Rini, Brian |
| Description | Author Affiliation: Al-Marrawi MY ( Cleveland Clinic Taussig Cancer Institute, R35, 9500 Euclid Avenue, Cleveland, OH 44195, USA. almarrm@ccf.org [corrected]) |
| Abstract | INTRODUCTION: Dramatic advances in the care of patients with advanced renal cell carcinoma (RCC) have occurred over the last 10 years. Insights into the molecular pathogenesis of this disease have elucidated the importance of signaling cascades related to angiogenesis in the management of RCC. Pazopanib is a novel, small-molecule tyrosine kinase inhibitor that targets vascular endothelial growth factor receptors (VEGFR)-1, -2, and -3; platelet-derived growth factor receptors (PDGFR)- and -ß; and c-kit tyrosine kinases. Pazopanib exhibits distinct pharmacokinetic and toxicity profiles compared with other agents in the class of VEGF signaling pathway inhibitors. AREAS COVERED: This review discusses the scientific rationale for the development of pazopanib, as well as the preclinical and clinical trials that led to the approval of pazopanib for patients with advanced RCC. The most recent information, including data from the 2010 meeting of the American Society of Clinical Oncology and the design of ongoing Phase III trials, is discussed. Finally, an algorithm utilizing level I evidence for the treatment of patients with this disease is proposed. EXPERT OPINION: The treatment of metastatic RCC has changed dramatically over the last 5 years. Six novel agents - sunitinib, sorafenib, temsirolimus, everolimus, bevacizumab (used in combination with interferon), and pazopanib (Votrient) - have been approved for the treatment of metastatic RCC. The clinical data to date clearly place pazopanib among the most active of the targeted therapies. |
| File Format | HTM / HTML |
| ISSN | 14656566 |
| Issue Number | 7 |
| Volume Number | 12 |
| e-ISSN | 17447666 |
| Journal | Expert Opinion on Pharmacotherapy |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2011-05-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Angiogenesis Inhibitors Therapeutic Use Antineoplastic Agents Adverse Effects Carcinoma, Renal Cell Drug Therapy Kidney Neoplasms Protein Kinase Inhibitors Pyrimidines Sulfonamides Chemistry Pharmacokinetics Pathology Secondary Clinical Trials As Topic Female Humans Male Molecular Targeted Therapy Receptors, Platelet-derived Growth Factor Antagonists & Inhibitors Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) |
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