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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rapkin, Rachel B. Creinin, Mitchell D. |
| Description | Country affiliation: United States Author Affiliation: Rapkin RB ( University of Pittsburgh, Magee Womens Hospital, 300 Halket Street, Pittsburgh, PA 15213, USA. beckerrk@mail.magee.edu) |
| Abstract | INTRODUCTION: Neural tube defects are the second most common congenital anomaly in the United States, although their incidence may be decreased by periconception folic acid supplementation. A new oral contraceptive containing drospirenone and ethinyl estradiol plus levomefolate calcium was formulated to decrease the risk of neural tube defects in pregnancies conceived while taking or shortly after discontinuing this pill. AREAS COVERED: Because of its novelty, very few studies have been performed to evaluate the efficacy, side effects and safety related to contraception, premenstrual dysphoric disorder and acne; therefore, literature evaluating similar contraceptives without levomefolate is reviewed. Additionally, we review studies evaluating the addition of levomefolate calcium to oral contraceptives containing 3 mg drospirenone and either 20 or 30 µg ethinyl estradiol. To date, no study has been performed to evaluate the effect this new oral contraceptive has on reducing the incidence of neural tube defects. EXPERT OPINION: This new pill has similar contraceptive efficacy, side effect, safety and benefits profile to other drospirenone-containing contraceptives. While also approved to prevent neural tube defects, no studies validate this claim and physician time is better spent counseling women, regardless of contraceptive choice, on the importance of folic acid supplementation during the child-bearing years. |
| File Format | HTM / HTML |
| ISSN | 14656566 |
| Issue Number | 15 |
| Volume Number | 12 |
| e-ISSN | 17447666 |
| Journal | Expert Opinion on Pharmacotherapy |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2011-10-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Androstenes Administration & Dosage Calcium Contraceptives, Oral, Combined Ethinyl Estradiol Glutamates Neural Tube Defects Prevention & Control Pharmacokinetics Pharmacology Female Humans Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) |
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