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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ozdemir, Suna Görkemli, Hüseyin Gezginç, Kazim Ozdemir, Mustafa Kiyici, Aysel |
| Description | Country affiliation: Turkey Author Affiliation: Ozdemir S ( Department of Gynecology and Obstetrics, Meram Medical Faculty, Selçuk University, Konya, Turkey. snmstf@yahoo.com) |
| Abstract | OBJECTIVES: To investigate the effects of treatment with medroxyprogesterone acetate (MPA), 10 days per month for 6 months, on lipid and carbohydrate metabolism in women with polycystic ovary syndrome (PCOS). METHODS: Sixty-three women with PCOS were randomized to receive MPA or ethinyl estradiol plus drospirenone. RESULTS: There were no changes in lipid or carbohydrate metabolism in the MPA group, but serum levels of luteinizing hormone (P<0.001) and total testosterone (P<0.003) significantly decreased, as did the free androgen index (P<0.02) and acne (P<0.03) and seborrhea (P<0.04) scores. In the ethinyl estradiol plus drospirenone group lipid and hormone values significantly increased whereas acne, seborrhea, hair loss, and Ferriman-Gallwey scores decreased. There was no statistically significant change in the total cholesterol to high-density cholesterol ratio in either group. CONCLUSION: Treatment of PCOS patients with MPA provided good menstrual cycle control, beneficial changes in hormonal values associated with hyperandrogenism, and no significant changes in lipid or carbohydrate metabolism. |
| File Format | HTM / HTML |
| ISSN | 00207292 |
| Issue Number | 1 |
| Volume Number | 103 |
| e-ISSN | 18793479 |
| Journal | International Journal of Gynecology & Obstetrics |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2008-10-01 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Polycystic Ovary Syndrome Humans Discipline Obstetrics Menstrual Cycle Blood Journal Article Young Adult Adult Female Medroxyprogesterone Acetate Contraceptive Agents, Female Drug Therapy Carbohydrate Metabolism Androstenes Contraceptives, Oral, Combined Lipid Metabolism Pharmacology Administration & Dosage Ethinyl Estradiol Metabolism Randomized Controlled Trial Drug Effects Cholesterol Physiopathology Luteinizing Hormone Testosterone Androgens Follow-up Studies Adolescent Discipline Gynecology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Obstetrics and Gynecology |
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