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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jayaweera, Dushyantha Dilanchian, Paula |
| Description | Country affiliation: United States Author Affiliation: Jayaweera D ( University of Miami Miller School of Medicine, Division of Infectious Diseases, Department of Medicine, Room 857 Clinical Research Bldg, 1120 NW 14th Street, Miami, FL 33136, USA. djayawee@med.miami.edu) |
| Abstract | INTRODUCTION: A key objective with highly active antiretroviral therapy for the treatment of HIV infection has been the optimization of antiretroviral drug combinations for individual patients. AREAS COVERED: Overall, non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimens (in combination with two nucleoside reverse transcriptase inhibitors (NRTIs)) have become mainstays for initial ARV regimens. Early NNRTIs, efavirenz and nevirapine, are similarly efficacious, but differ according to their toxicity profiles. Newer NNRTIs, rilpivirine and etravirine are also efficacious. Etravirine was designed to overcome common first-line NNRTI resistance mutations, and serves as a second line agent. EXPERT OPINION: As a class, NNRTIs are key components of ARV regimens. Currently, there are 3 NNRTIs that may be used in first-line regimens, and one in second-line regimens. ARV regimen optimization depends on matching individual drug efficacy, safety, resistance, and toxicity profiles to particular patients. Once-daily dosing options are essential to treatment simplification strategies, which have been shown to enhance regimen compliance and durabiltiy. These are especially important due to the low genetic barrier to resistance generally associated with NNRTIs. As newer drugs are introduced, especially as part of once-daily, single-tablet regimens, this will expand the number of convenient and efficacious treatment options available. |
| File Format | HTM / HTML |
| ISSN | 14656566 |
| Issue Number | 18 |
| Volume Number | 13 |
| e-ISSN | 17447666 |
| Journal | Expert Opinion on Pharmacotherapy |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2012-12-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Hiv Infections Drug Therapy Hiv Drug Effects Reverse Transcriptase Inhibitors Therapeutic Use Antiretroviral Therapy, Highly Active Trends Clinical Trials As Topic Drug Resistance, Viral Humans Nitriles Adverse Effects Pharmacokinetics Pyridazines Pyrimidines Rilpivirine Journal Article Research Support, Non-u.s. Gov't Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) |
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