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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jayaweera, Dushyantha T. Espinoza, Luis Castro, Jose |
| Description | Country affiliation: United States Author Affiliation: Jayaweera DT ( University of Miami Miller School of Medicine, 1200 NW 195TH Street, Suite 857, Miami, FL 33136, USA. dajayawee@med.miami.edu) |
| Abstract | BACKGROUND: Etravirine is the first non-nucleoside reverse transcriptase inhibitor (NNRTI) to be active against human immunodeficiency virus with NNRTI mutations. OBJECTIVE: To understand the unique features of etravirine and to evaluate its safety, efficacy, and optimal use. METHODS: The structure and the mechanism of action of etravirine in blocking the reverse transcriptase enzyme and the preclinical, pharmacokinetic and pharmacodynamic studies were reviewed. The DUET Phase III clinical trials and the resistance profile of etravirine were evaluated. CONCLUSIONS: Etravirine has unique activity against most HIV isolates that are resistant to other NNRTIs. Unlike other NNRTIs, it has a higher genetic barrier to developing high-grade resistance. In the DUET studies, etravirine demonstrated virological efficacy superior to the control arms with comparable rates of adverse events with the exception of rash. Because of its effect on the cytochrome P450 system, there are important drug interactions that will need to be taken into consideration with its use. |
| File Format | HTM / HTML |
| ISSN | 14656566 |
| Issue Number | 17 |
| Volume Number | 9 |
| e-ISSN | 17447666 |
| Journal | Expert Opinion on Pharmacotherapy |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2008-12-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Pyridazines Therapeutic Use Anti-hiv Agents Chemistry Pharmacology Clinical Trials As Topic Drug Resistance, Viral Drug Effects Hiv Infections Drug Therapy Humans Reverse Transcriptase Inhibitors Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) |
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