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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kornstein, Susan G. McIntyre, Roger S. Thase, Michael E. Boucher, Matthieu |
| Description | Author Affiliation: Kornstein SG ( Department of Psychiatry and Institute for Women's Health, Virginia Commonwealth University , PO Box 980319, Richmond, VA 23298-0319 , USA +1 804 827 1200 ) |
| Abstract | INTRODUCTION: Major depressive disorder (MDD) is a chronic and debilitating condition often characterized by inadequate treatment. Notwithstanding the availability of more than a dozen first-line agents across disparate classes (e.g., selective serotonin reuptake inhibitors), the majority of individuals with MDD do not achieve and sustain a recovered state. A substantial percentage of MDD patients require a treatment change due to poor efficacy or tolerability. AREAS COVERED: This review focuses on recent (≤ 5 years) literature describing the pharmacokinetics, efficacy, and tolerability of desvenlafaxine , one of the more recently approved antidepressant drugs. Published papers identified via PubMed search and congress presentations were included. Results from short-term, placebo-controlled, MDD trials and randomized withdrawal trials, as well as post hoc analyses in patient subgroups, are reviewed. EXPERT OPINION: Desvenlafaxine has been shown to be an effective antidepressant with a favorable safety and tolerability profile in the general MDD population and in important patient subgroups. It has several notable differences from other serotonin-norepinephrine reuptake inhibitors, and those differences suggest populations in which it may have the most clinical benefit. |
| File Format | HTM / HTML |
| ISSN | 14656566 |
| Issue Number | 10 |
| Volume Number | 15 |
| e-ISSN | 17447666 |
| Journal | Expert Opinion on Pharmacotherapy |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2014-07-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Antidepressive Agents Therapeutic Use Cyclohexanols Depressive Disorder, Major Drug Therapy Serotonin Uptake Inhibitors Pharmacokinetics Prevention & Control Desvenlafaxine Succinate Drug Interactions Humans Secondary Prevention Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) |
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