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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sagnelli, Evangelista Pisaturo, Mariantonietta Martini, Salvatore Sagnelli, Caterina Filippini, Pietro Coppola, Nicola |
| Description | Author Affiliation: Sagnelli E ( Department of Mental Health and Public Medicine, Division of Infectious Diseases, Second University of Naples , Naples , Italy +39 81 5560885 ) |
| Abstract | INTRODUCTION: Patients with chronic hepatitis B virus (HBV)/hepatitis C virus (HCV) coinfection are at a high risk of developing liver cirrhosis and hepatocellular carcinoma, and consequently, warrant effective treatment. AREAS COVERED: Effective treatment should eradicate HCV infection and inhibit HBV replication but without serious adverse reactions. Careful evaluation of disease progression, predominance of one virus over another, comorbidities and concomitant hepatitis delta virus and/or HIV infection are essential for better therapy choices. In the case of HCV predominance, Peg-interferon plus ribavirin with or without a first-generation directly acting antiviral (DAA) should be the first choice, but future treatments will be DAA-based and interferon-free. In the case of HBV predominance, tenofovir or entecavir should be part of treatment. Patients should be closely monitored for early identification and treatment of HCV or HBV reactivation. EXPERT OPINION: High potency and high genetic barrier nucleos(t)ide analogues to inhibit HBV replication have been used for years, with no urgency for new drugs. Several DAAs for interferon-free therapy for HCV eradication will be available in the near future. We hope that the high cost of these drugs will not be a limitation to their use in developing countries. Further investigation of HBV/HCV interaction is needed before and during the administration of new therapies. |
| File Format | HTM / HTML |
| ISSN | 14656566 |
| Issue Number | 10 |
| Volume Number | 15 |
| e-ISSN | 17447666 |
| Journal | Expert Opinion on Pharmacotherapy |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2014-07-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Antiviral Agents Therapeutic Use Hepacivirus Drug Effects Hepatitis B Virus Hepatitis B Drug Therapy Hepatitis C Adenine Analogs & Derivatives Coinfection Dna, Viral Isolation & Purification Drug Therapy, Combination Guanine Hiv Infections Complications Genetics Physiology Epidemiology Hepatitis C, Chronic Humans Organophosphonates Rna, Viral Ribavirin Tenofovir Virus Replication Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) |
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