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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lal, Chitra Strange, Charlie |
| Description | Author Affiliation: Lal C ( Medical University of South Carolina, Allergy and Sleep Medicine, Department of Pulmonary, Critical Care , 96 Jonathan Lucas Street, CSB 812, Msc 630, Charleston, SC 29425 , USA +1 843 792 7776 ) |
| Abstract | INTRODUCTION: Drugs that target dynamic hyperinflation such as long-acting ß-2 agonists and long-acting antimuscarinic antagonists form a cornerstone of chronic obstructive pulmonary disease (COPD) management. The idea of combining these two medications in a single formulation, which may potentially improve patient compliance, is novel and attractive. AREAS COVERED: The pharmacologic profiles of aclidinium bromide and formoterol fumarate are discussed. However, studies to define drug interactions and alterations in the pharmacodynamics and pharmacokinetics of the fixed dose combination (FDC) of aclidinium bromide/formoterol fumarate in large populations remain unpublished. Results of Phase II and two Phase III pivotal trials, ACLIFORM/COPD and AUGMENT COPD, evaluating the FDC are discussed. EXPERT OPINION: Initial data for the aclidinium/formoterol inhaler appears to be promising for impacting the lung function. To define if this benefit translates into improved long-term outcomes of decreased exacerbation frequency, improved quality of life and decreased disease-specific mortality are important. The introduction of this combination will likely have a significant impact on the prescribing habits of physicians across the world. |
| File Format | HTM / HTML |
| ISSN | 14656566 |
| Issue Number | 3 |
| Volume Number | 16 |
| e-ISSN | 17447666 |
| Journal | Expert Opinion on Pharmacotherapy |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2015-02-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Adrenergic Beta-2 Receptor Agonists Therapeutic Use Ethanolamines Muscarinic Antagonists Pulmonary Disease, Chronic Obstructive Drug Therapy Tropanes Administration, Inhalation Pharmacology Drug Therapy, Combination Formoterol Fumarate Humans Psychology Quality Of Life Journal Article Research Support, Non-u.s. Gov't Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) |
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