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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Elyasi, Sepideh Khalili, Hossein Dashti-Khavidaki, Simin Emadi-Koochak, Hamid |
| Description | Country affiliation: Iran Author Affiliation: Elyasi S ( Mashhad University of Medical Sciences, Department of Clinical Pharmacy, Faculty of Pharmacy , Mashhad , Iran.) |
| Abstract | OBJECTIVE: Efficacy of the conventional- versus high-dose vancomycin regimen in patients with acute bacterial meningitis was compared. METHODS: In a randomized clinical trial 44 patients with acute bacterial meningitis were randomly assigned to the conventional- or high-dose vancomycin groups. Clinical and laboratory parameters were used for evaluation of response to the treatment regimens. RESULTS: In the high-dose group, leukocytosis and fever resolved significantly faster than those in the conventional group. Furthermore, the length of hospitalization was shorter and Glasgow Coma Scale at the end of 10th day was significantly lower in the high dose compared to the conventional group. Trend of creatinine clearance changes did not differ significantly between the two groups. CONCLUSION: In comparison to the conventional-dose regimen, the high-dose vancomycin regimen was associated with significantly more favorable clinical response without increase in the incidence of nephrotoxicity in patients with acute bacterial meningitis. |
| File Format | HTM / HTML |
| ISSN | 14656566 |
| Issue Number | 3 |
| Volume Number | 16 |
| e-ISSN | 17447666 |
| Journal | Expert Opinion on Pharmacotherapy |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2015-02-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Anti-bacterial Agents Therapeutic Use Meningitis, Bacterial Drug Therapy Vancomycin Acute Disease Adult Adverse Effects Dose-response Relationship, Drug Humans Kidney Diseases Chemically Induced Middle Aged Comparative Study Journal Article Randomized Controlled Trial Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) |
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