NDLI: Cysteine turnover in human cell lines is influenced by glyphosate.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hultberg, Malin
Description	Country affiliation: Sweden Author Affiliation: Hultberg M ( Department of Crop Science, Swedish University of Agricultural Sciences, P.O. Box 44, 230 53 Alnarp, Sweden.)
Abstract	Pesticides are widely spread in the environment and there is a lack of knowledge concerning the impact of these substances on the human cell. In the present study the effect of low doses of the pesticides bentazon, metalaxyl and glyphosate on the cellular metabolism of glutathione and cysteine was examined in HeLa and hepatoma cell cultures. No effect was observed when the cells were exposed to bentazon or metalaxyl. However, significant changes in the intra- and extracellular concentration of cysteine, a precursor for glutathione synthesis, were detected when glyphosate was added to the medium. This finding was observed in the presence of micromolar concentration range of glyphosate, and is relevant when compared to concentrations observed in monitoring programmes.
File Format	HTM / HTML
ISSN	13826689
Issue Number	1
Journal	Environmental Toxicology and Pharmacology
Volume Number	24
e-ISSN	18727077
Language	English
Publisher	Elsevier
Publisher Date	2007-07-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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Cysteine turnover in human cell lines is influenced by glyphosate.