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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Manerikar, Rajesh Shridhar Apte, Akshaya Arvind Ghole, Vikram Shantaram |
| Description | Country affiliation: India Author Affiliation: Manerikar RS ( Department of Environmental Sciences, University of Pune, Pune 411007, India.) |
| Abstract | Hexavalent chromium is the major terrestrial pollutant released from electroplating industries, tanneries, thermal power plants and sewage. Cr(VI) is reported genotoxicant in vertebrates. Sub-lethal level of Cr(VI) can cause DNA damage. Earthworms are ecologically important soil invertebrates, used for ecotoxicological studies. In present study coelomocytes of Dichogaster curgensis were used for assessing Cr(VI) genotoxicity using single cell gel electrophoresis [(SCGE) i.e. comet assay] following in vitro and in vivo exposures. Cr(VI) produces reactive oxygen species (ROS) in the cellular system, which can be a major cause of DNA damage. Dose dependent DNA damage was observed during in vitro exposure, while in vivo exposure showed increasing DNA damage till 30ppm in terms of arbitrary units and unexpected decrease in arbitrary units at 70 and 100ppm of Cr(VI). It is speculated that the decrease in arbitrary units at higher concentrations might be due to lower DNA mobility, caused by formation of different types of cross-links. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 1 |
| Journal | Environmental Toxicology and Pharmacology |
| Volume Number | 25 |
| e-ISSN | 18727077 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-01-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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