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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Pillai, Thulasi G. Nair, Cherupally Krishnan Krishnan Janardhanan, K. K. |
| Description | Country affiliation: India Author Affiliation: Pillai TG ( Amala Cancer Research Centre, Amalanagar, Thrissur, Kerala, India.) |
| Abstract | The in vivo and in vitro radioprotective property of the polysaccharides isolated from Ganoderma lucidum were determined by survival studies, induction of micronucleus in reticulocytes of mice, strand breaks in plasmid pBR322 DNA and inhibition of lipid peroxidation (TBARS assay). Polysaccharides were administered as a single dose after whole body exposure to 10Gy (60)Co γ-radiation to Swiss albino mice. At a dose of 500µg/kg body wt, the polysaccharides were most effective in protecting animals from radiation induced loss of lethality. Administration of 500µg/kg body wt to animal exposed to 10Gy gamma radiation resulted in more than 60% survival on the 30th day compared to the dose of 300mg/kg/body wt administration of amifostine, a clinically used radioprotective drug. The induction of micronuclei was reduced by the administration of polysaccharides. The decrease in micronuclei induction was dose dependent. Thus following 4Gy exposure the micronuclei in polychromatic erythrocytes (MNCE) was reduced from 28.16±3.049 to 16.0243±2.074 and 6.30±2.422 by polysaccharides at doses of 250µg/kg body wt and 500µg/kg body wt, respectively, and to 10.4±2.581 by amifostine at a dose of 300mg/kg body wt. The results indicate the significant protective effect of Ganoderma polysaccharides against radiation induced damages. The findings thus suggest the potential use of Ganoderma polysaccharides as novel radioprotective agent. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 1 |
| Journal | Environmental Toxicology and Pharmacology |
| Volume Number | 26 |
| e-ISSN | 18727077 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-07-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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