NDLI: Alteration of serum sex hormonal profile in male gasoline filling station workers in respect to their polymorphism of glutathione S-transferase M1.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Saadat, Mostafa Bahaoddini, Samaneh Saadat, Iraj
Spatial Coverage	Iran
Description	Country affiliation: Iran Author Affiliation: Saadat M ( Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran. saadat@shirazu.ac.ir)
Abstract	Alterations in offspring sex ratio at birth and level of serum testosterone in filling-station workers have been reported. To determine the association of glutathione S-transferase M1 (GSTM1) polymorphism with serum levels of total testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) of male filling-station workers, the present study was carried out on 114 gasoline workers and 100 age- and sex-matched controls with no occupational exposure to gasoline. We have found no significant difference between the workers and controls for levels of sex hormones in the presence of active GSTM1 genotype. Among subjects with the GSTM1 null genotype, there was significant difference between exposed and unexposed subjects for the concentration of testosterone (t=4.37, df=97, P<0.001). To investigate whether one null genotype could be compensated by an active genotype for the other isoenzyme, the mean concentrations of sex hormones was compared between the exposed and control groups with respect to their combinations of the GSTM1 and GSTT1 genotypes. The exposed group having either 'null GSTM1/positive GSTT1' (t=2.76, df=72, P=0.007) or 'null GSTM1/null GSTT1' (t=4.91, df=23, P<0.001) combinations had a lower testosterone compared with the controls. It seems that GSTM1 polymorphism has more effect on serum testosterone compared to the GSTT1 polymorphism, in exposed workers.
File Format	HTM / HTML
ISSN	13826689
Issue Number	2
Volume Number	35
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2013-03-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Gasoline Adverse Effects Glutathione Transferase Genetics Gonadal Steroid Hormones Blood Occupational Exposure Testosterone Adult Case-control Studies Follicle Stimulating Hormone Humans Iran Luteinizing Hormone Male Middle Aged Polymorphism, Genetic Young Adult Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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