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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rayees, Sheikh Sharma, Rohit Singh, Gurdarshan Najar, Ishtiyaq Ahmad Singh, Amarinder Ahamad, Dastagir Basheer Sharma, Subash Chander Tikoo, Manoj Kumar Gupta, Vijay Kumar Sangwan, Payare Lal Singh, Surjeet Koul, Surinder Johri, Rakesh Kamal |
| Description | Country affiliation: India Author Affiliation: Rayees S ( PK-PD Toxicology Division, Indian Institute of Integrative Medicine, CSIR, Jammu 180001, India.) |
| Abstract | An efflux pump inhibitor, SK-20 (5-(3,4-methylenedioxyphenyle)-4 ethyl-2E,4E-pentadienoic acid piperidide), was assessed for its toxicity at three different pharmacological profiles: acute, sub-acute and general pharmacology with pharmacokinetics. In acute study, the SK-20 was found safe up to a dose of 2000 mg/kg (b.wt.); and at sub-acute, dosages of 50 and 100 mg/kg (b.wt.) were found to be safe. However, dosages of 200 mg or above per kg (b.wt.) showed some morphological alterations in cellular architecture of both liver and kidneys in both sexes, viz., mild vascular congestion along with sporadic hemorrhages and infiltration into renal and hepatic parenchyma by mononucleate cell. General pharmacological studies did not result into any alterations in analgesic, convulsions, rectal temperatures and in the rhythm or the rate of the intestinal motility or the secretion of the bile. While the respiratory and the cardiac rate remained normal, the only parameter to show was the blood pressure, which at all the doses tested, showed a tendency toward reduction. Characteristically, the SK-20 at all doses influenced pentobarbital-induced hypnosis positively and negatively to spontaneous motor activity in a dose dependent manner. Pharmacokinetics of SK-20 revealed it to have retention time at 10.2 min and half life 2.47 h. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 2 |
| Volume Number | 35 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-03-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Benzodioxoles Pharmacology Piperidines Toxicity Tests, Acute Toxicity Tests, Subacute Analgesics Animals Anticonvulsants Blood Drug Effects Body Temperature Body Weight Dose-response Relationship, Drug Drug Stability Female Kidney Liver Male Mice Motor Activity Organ Size Pentobarbital Polyunsaturated Alkamides Rats Rats, Wistar Sleep Urinalysis Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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