NDLI: Effect of cardiac glycosides from Nerium indicum on feeding rate, digestive enzymes activity and ultrastructural alterations of hepatopancreas in Pomacea canaliculata.

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Effect of cardiac glycosides from Nerium indicum on feeding rate, digestive enzymes activity and ultrastructural alterations of hepatopancreas in Pomacea canaliculata.

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Effect of cardiac glycosides from Nerium indicum on feeding rate, digestive enzymes activity and ultrastructural alterations of hepatopancreas in Pomacea canaliculata.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dai, Lingpeng Qian, Xiaowei Nan, Xuyang Zhang, Yejian
Description	Author Affiliation: Dai L ( School of Life and Environmental Science, Wenzhou University, Wenzhou 325035, PR China. Electronic address: lpdai825@126.com.); Qian X ( School of Life and Environmental Science, Wenzhou University, Wenzhou 325035, PR China.); Nan X ( School of Life and Environmental Science, Wenzhou University, Wenzhou 325035, PR China.); Zhang Y ( School of Life and Environmental Science, Wenzhou University, Wenzhou 325035, PR China.)
Abstract	Cardiac glycosides from Nerium indicum showed potent molluscicide activity against Pomacea canaliculata (GAS), but the toxicological mechanism is still far less understood. Effects of sublethal treatments of cardiac glycosides on feeding rate, digestive enzymes and ultrastructural alterations of the hepatopancreas in GAS were evaluated in this study. Exposure of GAS to sublethal concentrations of cardiac glycosides resulted in a significant reduction of feeding rate of GAS. The amylase, cellulose and protease activity were increase significantly at the end of 24 h followed by significant inhibition after 48 h of exposure while lipase activity was not affected significantly at the end of 24 h followed by a significant inhibition after 48 h of exposure during experimental period. The main ultrastructural alterations of hepatopancreas observed in snails under cardiac glycosides treatment comprised disruption of nuclear membrane, increased vesiculation and dilatation of endoplasmic reticulum, and vacuolization and swelling of mitochondrial compared to the untreated GAS. These results, for the first time, provide systematic evidences showing that cardiac glycosides seriously impairs the hepatopancreas tissues of GAS, resulting in inhibition of digestive enzymes activity and feeding rate and cause GAS death in the end.
File Format	HTM / HTML
ISSN	13826689
Issue Number	1
Volume Number	37
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2014-01-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Cardiac Glycosides Pharmacology Eating Drug Effects Hepatopancreas Nerium Snails Amylases Metabolism Animals Cellulose Enzymology Ultrastructure Lipase Microscopy, Electron, Transmission Peptide Hydrolases Plant Leaves Physiology Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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