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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Shen, Zhaoxia Zhu, Dongmei Liu, Jiao Chen, Juan Liu, Yun Hu, Chunyan Li, Zhong Li, Yuan |
| Description | Country affiliation: China Author Affiliation: Shen Z ( Department of Nutrition and Food Hygiene, School of Public Health, Nanjing Medical University, Nanjing 211166, China); Zhu D ( Department of Nutrition and Food Hygiene, School of Public Health, Nanjing Medical University, Nanjing 211166, China); Liu J ( Department of Nutrition and Food Hygiene, School of Public Health, Nanjing Medical University, Nanjing 211166, China); Chen J ( Department of Nutrition and Food Hygiene, School of Public Health, Nanjing Medical University, Nanjing 211166, China); Liu Y ( Department of Nutrition and Food Hygiene, School of Public Health, Nanjing Medical University, Nanjing 211166, China); Hu C ( Department of Nutrition and Food Hygiene, School of Public Health, Nanjing Medical University, Nanjing 211166, China); Li Z ( Department of Nutrition and Food Hygiene, School of Public Health, Nanjing Medical University, Nanjing 211166, China); Li Y ( Department of Nutrition and Food Hygiene, School of Public Health, Nanjing Medical University, Nanjing 211166, China) |
| Abstract | Breast carcinoma plays a vital role in the reasons of global women's death. ER-related invasion and migration play an important part in the development and prognosis of breast cancer. Here, we found that 27-Hydroxycholesterol (27HC) could induce epithelial-mesenchymal transition (EMT) and increase the expression of the matrix metalloproteinase 9 (MMP9) at mRNA level and the active form. Meanwhile, interestingly, we found 27HC activated signal transducer and activator of transcription 3 (STAT-3) in ER positive cells except activation of ER signaling. Furthermore, inhibition of STAT-3 by siRNA attenuated the 27HC-induced improvement of MMP9 and decreased the invasion and migration ability in MCF7 and T47D cells. In addition, 27HC could also promote MMP9, vimentin and active STAT-3 in the ER negative cells MDA-MB-231. All these results not only raise a mechanism whereby 27HC enhances the invasion and metastasis, but also is helpful to realize 27HC as a potential endogenous detrimental factor in breast tumor patients. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Journal | Environmental Toxicology and Pharmacology |
| Volume Number | 51 |
| e-ISSN | 18727077 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2017-02-10 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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