Suppression of ferroportin expression by cadmium stimulates proliferation, EMT, and migration in triple-negative breast cancer cells

Content Provider	Scilit
Author	Shan, Zhongguo Wei, Zhengxi Shaikh, Zahir A.
Copyright Year	2018
Description	Journal: Toxicology and Applied Pharmacology Cadmium (Cd) has been linked to a variety of cancers, including breast cancer; however, the molecular mechanism of its carcinogenic activity is not fully understood. To this end, the present study investigated the roles of ferroportin (FPN), a prognostic marker of breast cancer, in Cd-induced stimulation of cell proliferation and cell migration. Triple-negative MDA-MB-231 cells were treated with 1–3 μM Cd. The cells exhibited significant reduction in FPN expression and concomitant increase in iron concentration. Cells treated with Cd for 8 weeks displayed elevated proliferative and migratory activities which were inversely related with FPN expression. Reduced FPN expression also resulted in epithelial-mesenchymal transition as indicated by an increase in the expression of E-cadherin, and a decrease in the expression of N-cadherin, Twist and Slug. Further investigation revealed that Cd suppressed FPN expression at least partially by activating TGF-β, a known regulator of FPN expression. Taken together, these results indicate that Cd-induced stimulation of MDA-MB-231 cell proliferation, EMT, and migration is brought about by suppression of FPN expression and associated disruption of iron homeostasis.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157278/pdf
Ending Page	43
Page Count	8
Starting Page	36
ISSN	0041008X
e-ISSN	10960333
DOI	10.1016/j.taap.2018.07.017
Journal	Toxicology and Applied Pharmacology
Volume Number	356
Language	English
Publisher	Elsevier BV
Publisher Date	2018-07-17
Access Restriction	Open
Subject Keyword	Journal: Toxicology and Applied Pharmacology Breast Cancer
Content Type	Text
Resource Type	Article
Subject	Toxicology Pharmacology